The role of neutrophils in the inflammatory response during type 2 Diabetes mellitus: cellular and molecular mechanisms

• Grant number: 15/03175-1
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2015
• End date: August 31, 2017
• Field of knowledge: Biological Sciences - Physiology - General Physiology
• Principal Investigator: Tatiana Carolina Alba Loureiro
• Grantee: Tatiana Carolina Alba Loureiro
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Several epigenetic factors, such as excessive consumption of calories through fast food, reduced fiber intake and sedentary lifestyle, and psychosocial factors, including the decrease in sleep duration and depression are contributing to the increasing incidence of diabetes mellitus type 2 both in Brazilian population as the world. Whereas diabetic patients had a worsened prognosis inflammatory installed and that the infection is recognized as a possible cause of morbidity and mortality in these patients, this project aims to investigate the role of neutrophils, cells that act on the first line of defense in our body, in the inflammatory response using an experimental model of type 2 diabetes mellitus. For this purpose, cellular functions will be evaluated, such as: cell death, phagocytic capacity, myeloperoxidase activity, production of reactive oxygen species, production/liberation of cytokines, components of NADPH oxidase and the expression of genes involved with the inflammatory response per se as those related to the essential functions of neutrophils. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TATAGIBA KUWABARA, WILSON MITSUO; FUKUSAWA YOKOTA, CAROLINE NAOMI; CURI, RUI; ALBA-LOUREIRO, TATIANA CAROLINA. Obesity and Type 2 Diabetes mellitus induce lipopolysaccharide tolerance in rat neutrophils. SCIENTIFIC REPORTS, v. 8, DEC 3 2018. (16/15766-7, 18/09868-7, 15/03175-1)

TATAGIBA KUWABARA, WILSON MITSUO; PANVELOSKI-COSTA, ANA CAROLINA; FUKUSAWA YOKOTA, CAROLINE NAOMI; BERTAGLIA PEREIRA, JOICE NAIARA; MANCINI FILHO, JORGE; TORRES, ROSANGELA PAVAN; HIRABARA, SANDRO MASSAO; CURI, RUI; ALBA-LOUREIRO, TATIANA CAROLINA. Comparison of Goto-Kakizaki rats and high fat diet-induced obese rats: Are they reliable models to study Type 2 Diabetes mellitus?. PLoS One, v. 12, n. 12, DEC 8 2017. (15/03175-1)

TATAGIBA KUWABARA, WILSON MITSUO; CURI, RUI; ALBA-LOUREIRO, TATIANA CAROLINA. Autophagy Is Impaired in Neutrophils from Streptozotocin-Induced Diabetic Rats. FRONTIERS IN IMMUNOLOGY, v. 8, JAN 20 2017. (15/03175-1, 10/12818-0)