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Effects of systemically-administered curcumin on the cellular response pattern in periodontal disease model in vivo.

Grant number: 12/00820-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2012
Effective date (End): May 31, 2013
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal researcher:Morgana Rodrigues Guimarães Stabili
Grantee:Giovanna Righetti Bravo
Home Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Curcumin is a plant-derived dietary spice with various biological activities, including anti-tumoral and anti-inflammatory. Its therapeutic applications have been studied in a variety of conditions, such as rheumatoid arthritis, colon cancer and depression, diabetes and colitis. The anti-inflammatory properties of curcumin seem are mediated by the modulating the activity of signaling pathways and transcription factors, especially NF-KB, AP-1 and MAPKinases. Besides, studies have showed that curcumin can modulate the growth and cellular response of various cell types involved in the immune response including T and B lymphocytes, macrophages, neutrophils, NK cells and dendritic cells. However, studies about the role of curcumin on modulation of cellular immune response pattern are relatively unknown. The hypothesis of this work is that curcumin can modulate the immune response pattern of T cells in a model of ligature-induced periodontal disease in rats. To evaluate this hypothesis we will assess the effect of curcumin on mRNA expression of T cells cytokines polarized into a Th1, Th-2, Th-17 Treg-type phenotype in the periodontal tissues and whole blood of animals by RT-qPCR. The effect of curcumin on the stereometry analysis of the histological characteristics of gingival tissues subjected to ligature-induced periodontal disease also will be evaluate and the proportion of inflammatory cells and other cellular components will be compared in the diferent experimental groups.

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