Selenium and tellurium reagents in organic synthesis

• Grant number: 00/01011-6
• Support Opportunities: Research Projects - Thematic Grants
• Start date: August 01, 2000
• End date: May 31, 2005
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: João Valdir Comasseto
• Grantee: João Valdir Comasseto
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Hydrotelluration of alkynes Vinylic substitution reactions with seleno - and tellurolate anions Coupling reactions between vinylic tellurides and lower order cyanocuprates Coupling reaction between alylic cuprates and enoltriflates Coupling reaction between vinylic tellurides and alkynes catalyzed by paltadium. Bergman cyclization of the formed products Chiral aziridine opening by higher order Z vinyl cuprates Coupling of alkyltellurides with organometallic compounds Enzymatic synthesis of chiral y-butyrolactones Reduction of diorganotellurium dichlorides to the corresponding tellurides Hydroxylation of aromatic selenides and tellurides Kinetic resolution of vinylic tellurides Application of the reaction studied in the synthesis of bioactive compounds. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CUNHA‚ R.L.O.R.; URANO‚ M.E.; CHAGAS‚ J.R.; ALMEIDA‚ P.C.; BINCOLETTO‚ C.; TERSARIOL‚ I.L.S.; COMASSETO‚ J.V.. Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium (IV) compounds as inhibitors of human cathepsin B. Bioorganic & Medicinal Chemistry Letters, v. 15, n. 3, p. 755-760, 2005. (00/01011-6)