INCORPORATION AND RELEASE OF DRUGS BY SERICIN-ALGINATE MICROPARTICLES

• Grant number: 15/13505-9
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2015
• End date: August 31, 2017
• Field of knowledge: Engineering - Chemical Engineering - Industrial Operations and Equipment for Chemical Engineering
• Principal Investigator: Melissa Gurgel Adeodato Vieira
• Grantee: Melissa Gurgel Adeodato Vieira
• Host Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Jacyara Moreira Martins Vidart ; Marcelino Luiz Gimenes ; Meuris Gurgel Carlos da Silva ; Paulo César Pires Rosa

Abstract

This project aims to develop pharmaceutical forms of modified release from the microencapsulation of drugs in sericin-alginate microparticles, which may allow better control of drug release rates in the body and / or delay drug release (formulations gastro) when administered orally, resulting in reduced side effects caused by toxic levels achieved due to the peak drug release into the bloodstream. Sericin used in this study will be obtained by the extraction process of the Bombyx mori cocoon species, while the alginate is commercially available. The drugs to be investigated are, at first, the diclofenac sodium and/or paracetamol as a model, and other pharmaceuticals to be defined according to the need for modified release formulation due to side effects caused by existing formulations, such as oxytetracycline, aceclofenac and valacyclovir. (AU)

Scientific publications

(15)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FREITAS, EMANUELLE D.; VIDART, JACYARA M. M.; SILVA, EDSON A.; DA SILVA, MEURIS G. C.; VIEIRA, MELISSA G. A.. Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery. PARTICUOLOGY, v. 41, p. 65-73, DEC 2018. (15/13505-9, 16/05007-1)

DE FREITAS, EMANUELLE DANTAS; PIRES ROSA, PAULO CESAR; CARLOS DA SILVA, MEURIS GURGEL; ADEODATO VIEIRA, MELISSA GURGEL. Development of sericin/alginate beads of ketoprofen using experimental design: Formulation and in vitro dissolution evaluation. Powder Technology, v. 335, p. 315-326, JUL 15 2018. (15/13505-9, 16/05007-1)

BEZERRA, IEDA CECILIA SALDANHA; DE FREITAS, EMANUELLE DANTAS; DA SILVA, MEURIS GURGEL CARLOS; VIEIRA, MELISSA GURGEL ADEODATO. Synthesis and characterization of furosemide-loaded sericin/alginate beads subjected to thermal or chemical cross-linking for delayed and sustained release. POLYMERS FOR ADVANCED TECHNOLOGIES, v. 32, n. 2, p. 461-473, FEB 2021. (15/13505-9)

VIDART, JACYARA M. M.; NAKASHIMA, MARIANA; DA SILVA, THIAGO L.; ROSA, PAULO C. P.; GIMENES, MARCELINO L.; VIEIRA, MELISSA G. A.; DA SILVA, MEURIS G. C.; VARBANOV, PS; LIEW, PY; YONG, JY; et al. Sericin and Alginate Blend as Matrix for Incorporation of Diclofenac Sodium. PRES2016: 19TH INTERNATIONAL CONFERENCE ON PROCESS INTEGRATION, MODELING AND OPTIMIZATION FOR ENERGY SAVINGS AND POLLUTION REDUCTION, v. 52, p. 6-pg., 2016-01-01. (15/13505-9)

DE ANDRADE, JULIA R.; DA SILVA, MEURIS G. C.; GIMENES, MARCELINO L.; VIEIRA, MELISSA G. A.; VARBANOV, PS; LIEW, PY; YONG, JY; KLEMES, JJ; LAM, HL. Equilibrium and Thermodynamic Studies on Adsorption of Trivalent Chromium by Sericin-Alginate Particles Prepared from Bombyx Mori Cocoons. PRES2016: 19TH INTERNATIONAL CONFERENCE ON PROCESS INTEGRATION, MODELING AND OPTIMIZATION FOR ENERGY SAVINGS AND POLLUTION REDUCTION, v. 52, p. 6-pg., 2016-01-01. (15/13505-9)

DE FREITAS, EMANUELLE DANTAS; LIMA, BEATRIZ MAYUMI; PIRES ROSA, PAULO CESAR; CARLOS DA SILVA, MEURIS GURGEL; ADEODATO VIEIRA, MELISSA GURGEL. Evaluation of proanthocyanidin- crosslinked sericin/alginate blend for ketoprofen extended release. ADVANCED POWDER TECHNOLOGY, v. 30, n. 8, p. 1531-1543, AUG 2019. (15/13505-9, 16/05007-1)

MARTINS VIDART, JACYARA MOREIRA; DA SILVA, THIAGO LOPES; PIRES ROSA, PAULO CESAR; ADEODATO VIEIRA, MELISSA GURGEL; CARLOS DA SILVA, MEURIS GURGEL. Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium. Journal of Applied Polymer Science, v. 135, n. 12, MAR 20 2018. (15/13505-9)

DE ANDRADE, JULIA RESENDE; CARLOS DA SILVA, MEURIS GURGEL; GIMENES, MARCELINO LUIZ; ADEODATO VIEIRA, MELISSA GURGEL. Bioadsorption of trivalent and hexavalent chromium from aqueous solutions by sericin-alginate particles produced from Bombyx mori cocoons. Environmental Science and Pollution Research, v. 25, n. 26, p. 25967-25982, SEP 2018. (15/13505-9)

SANTINON, CAROLINE; DE FREITAS, EMANUELLE DANTAS; CARLOS DA SILVA, MEURIS GURGEL; ADEODATO VIEIRA, MELISSA GURGEL. Modification of valsartan drug release by incorporation into sericin/alginate blend using experimental design methodology. EUROPEAN POLYMER JOURNAL, v. 153, JUN 15 2021. (16/05007-1, 15/13505-9)

FREITAS, E. D.; ROSA, P. C. P.; SILVA, M. G. C.; VIEIRA, M. G. A.. Application of experimental design to evaluate the incorporation of naproxen into sericin/alginate particles prepared by ionic gelation technique. Chemical Engineering Science, v. 229, JAN 16 2021. (15/13505-9, 16/05007-1)

FREITAS, EMANUELLE D.; FREITAS, VITORIA M. S.; ROSA, PAULO C. P.; DA SILVA, MEURIS G. C.; VIEIRA, MELISSA G. A.. Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents. Materials Science & Engineering C-Materials for Biological Applications, v. 118, JAN 2021. (15/13505-9, 16/05007-1)

FREITAS, EMANUELLE D.; VIDART, JACYARA M. M.; DA SILVA, MEURIS G. C.; VIEIRA, MELISSA G. A.. Thermal characterization and stability investigation of sericin and alginate blend loaded with diclofenac sodium or ibuprofen. EUROPEAN POLYMER JOURNAL, v. 142, JAN 5 2021. (15/13505-9, 16/05007-1)

BEZERRA, IEDA C. S.; MOMA, MARYENNE S. M.; FREITAS, EMANUELLE D.; SILVA, MEURIS G. C.; VIEIRA, MELISSA G. A.. Development of a modified drug delivery system through the incorporation of furosemide into sericin and alginate matrix using the experimental design approach. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, v. 96, n. 3, p. 650-661, MAR 2021. (15/13505-9)

SANTINON, CAROLINE; BORGES, DANIELE; CARLOS DA SILVA, MEURIS GURGEL; ADEODATO VIEIRA, MELISSA GURGEL. Evaluation of different covalent crosslinking agents into valsartan-loaded sericin and alginate particles for modified release. Powder Technology, v. 390, p. 240-255, SEP 2021. (16/05007-1, 15/13505-9)

DE ANDRADE, JULIA RESENDE; CARLOS DA SILVA, MEURIS GURGEL; GIMENES, MARCELINO LUIZ; ADEODATO VIEIRA, MELISSA GURGEL. Bioadsorption of trivalent and hexavalent chromium from aqueous solutions by sericin-alginate particles produced from Bombyx mori cocoons. Environmental Science and Pollution Research, v. 25, n. 26, p. 16-pg., 2018-09-01. (15/13505-9)

Filed patent(s) as a result of this research project