Fluoride (F) metabolism/body F retention: effects of host (genetic variation) and environment (F dose and exercise) factors

• Grant number: 14/50798-1
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2015
• End date: January 31, 2017
• Field of knowledge: Health Sciences - Dentistry - Social and Preventive Dentistry
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Marília Afonso Rabelo Buzalaf
• Grantee: Marília Afonso Rabelo Buzalaf
• Principal researcher abroad: Ruth Valentine
• Institution abroad: Newcastle University, England
• Principal researcher abroad: Vida Zohoori
• Institution abroad: Teeside University, England
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
• Associated research grant: 12/16840-5 - Fluoride toxicology: proteomic studies in gut and liver, AP.R

Abstract

The scientific importance of fluorides (F) is well recognised; they have a fundamental role in achieving and maintaining oral health and F status is of nutritional and public health significance. The use of fluoridated water one of the most important public health measures world-wide which has resulted in dramatic reductions of dental caries. Community water fluoridation schemes commenced in the early 1960's in parts of the UK and now approximately 10% of the UK's population receives fluoridated water adjusted to a target concentration of 1 ppm F. In contrast, in the State of São Paulo (Brazil) water fluoridation schemes have been in place since the early 1970S and they now reach 90% of the population. Aims of the SPRINT proposal: to promote the engagement of researchers from Newcastle and Teesside Universities, UK with those from University of Sao Paulo and Sao Paulo State University, Brazil, by strengthening their existing research collaboration through the development and submission of 3 research proposals: short-, medium- and long-term addressing the following research question: 1. What are the effects of i) genet variation (host); ii) F dose and exercise (environment) on F metabolism and body retention?; 2. How does any interaction between host and environment affect F metabolism and body F retention? (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDES, MILENI S.; SABINO-ARIAS, ISABELA T.; DIONIZIO, ALINE; FABRICIO, MAYARA F.; TREVIZOL, JULIANA S.; MARTINI, TATIANA; AZEVEDO, LIANE B.; VALENTINE, RUTH A.; MAGUIRE, ANNE; ZOHOORI, FATEMEH, V; et al. Effect of Physical Exercise and Genetic Background on Glucose Homeostasis and Liver/Muscle Proteomes in Mice. METABOLITES, v. 12, n. 2, p. 22-pg., 2022-02-01. (16/20020-4, 15/50406-9, 14/50798-1, 15/12109-2)