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Fluoride (F) metabolism/body F retention: effects of host (genetic variation) and environment (F dose and exercise) factors

Grant number: 14/50798-1
Support Opportunities:Regular Research Grants
Duration: February 01, 2015 - January 31, 2017
Field of knowledge:Health Sciences - Dentistry - Social and Preventive Dentistry
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Marília Afonso Rabelo Buzalaf
Grantee:Marília Afonso Rabelo Buzalaf
Principal researcher abroad: Ruth Valentine
Institution abroad: Newcastle University, England
Principal researcher abroad: Vida Zohoori
Institution abroad: Teeside University, England
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated research grant:12/16840-5 - Fluoride toxicology: proteomic studies in gut and liver, AP.R

Abstract

The scientific importance of fluorides (F) is well recognised; they have a fundamental role in achieving and maintaining oral health and F status is of nutritional and public health significance. The use of fluoridated water one of the most important public health measures world-wide which has resulted in dramatic reductions of dental caries. Community water fluoridation schemes commenced in the early 1960's in parts of the UK and now approximately 10% of the UK's population receives fluoridated water adjusted to a target concentration of 1 ppm F. In contrast, in the State of São Paulo (Brazil) water fluoridation schemes have been in place since the early 1970S and they now reach 90% of the population. Aims of the SPRINT proposal: to promote the engagement of researchers from Newcastle and Teesside Universities, UK with those from University of Sao Paulo and Sao Paulo State University, Brazil, by strengthening their existing research collaboration through the development and submission of 3 research proposals: short-, medium- and long-term addressing the following research question: 1. What are the effects of i) genet variation (host); ii) F dose and exercise (environment) on F metabolism and body retention?; 2. How does any interaction between host and environment affect F metabolism and body F retention? (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERNANDES, MILENI S.; SABINO-ARIAS, ISABELA T.; DIONIZIO, ALINE; FABRICIO, MAYARA F.; TREVIZOL, JULIANA S.; MARTINI, TATIANA; AZEVEDO, LIANE B.; VALENTINE, RUTH A.; MAGUIRE, ANNE; ZOHOORI, FATEMEH, V; et al. Effect of Physical Exercise and Genetic Background on Glucose Homeostasis and Liver/Muscle Proteomes in Mice. METABOLITES, v. 12, n. 2, p. 22-pg., . (16/20020-4, 15/50406-9, 14/50798-1, 15/12109-2)

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