The aerobic training method can determine the existence of cardiac remodeling: structural, functional and molecular analyzes of swimming and running experimental models.

• Grant number: 15/11028-9
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2015
• End date: October 31, 2017
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Andrey Jorge Serra
• Grantee: Andrey Jorge Serra
• Host Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
• Associated researchers: Adriana Castello Costa Girardi ; José Antonio Silva Junior ; Paulo Jose Ferreira Tucci

Abstract

Physical training imposes structural, functional and molecular changes in the heart, which is an adaptive response called physiological cardiac hypertrophy. An issue that raises strong interest is the specific cardiac adaptive response according training modality. Thus, an increased thickness left ventricular (LV) wall as well as reduced LV cavity it has been shown to occur after anaerobic training, which is known as concentric LV hypertrophy. On the other hand, aerobic training induce eccentric cavity remodeling, which show be expressed by an increase in the cavity radius and maintenance or negligible change of wall thickness. Overall, this information led to assume that the cardiac remodeling induced by exercise is a clear issue. However, some issues have shown an opposite position - there is evidence that different types of aerobic exercise training can trigger a distinct parameter of cardiac remodeling. These data support our study, which will be developed on two experimental models (swimming and running) of aerobic exercise training commonly applied to induce cardiac remodeling in rodents. The use of experimental exercise model is suitable for our interest: [1] cardiac remodeling is similar in rats and humans; [2] load, volume, duration and adherence to training program are easily controlled; [3] an exact hypertrophic pattern in response to different aerobic training protocols is also a hypothesis to be defined at experimental models. In fact, our study will provide the following information: [1] swimming and running training programs induce similar morphologic changes in LV; [2] two protocols can induce improvement in LV performance and myocardial inotropic. Moreover, the molecular mechanisms linked to the adaptive process will not be neglected. We will assess whether the swimming and running training can modulate signaling pathway of PI3Kp110alpha/Akt/mTOR, which is critical to cardiac remodeling induced by exercise. The role of training programs on myocardial microRNA's expression is another target of this study. (AU)

Scientific publications

(21)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOS SANTOS, SOLANGE ALMEIDA; SERRA, ANDREY JORGE; STANCKER, TATIANE GARCIA; BRANDAO SIMOES, MAIRA CECILIA; DOS SANTOS VIEIRA, MARCIA ATAIZE; LEAL-JUNIOR, ERNESTO CESAR; PROKIC, MARKO; VASCONSUELO, ANDREA; SANTOS, SIMONE SILVA; CAMILLO DE CARVALHO, PAULO DE TARSO. Effects of Photobiomodulation Therapy on Oxidative Stress in Muscle Injury Animal Models: A Systematic Review. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017. (15/11028-9, 15/13677-4)

FELICIANO, REGIANE DOS SANTOS; BARBOZA ATUM, ALLAN LUIS; DA SILVA RUIZ, ERICO GUSTAVO; SERRA, ANDREY JORGE; ANTONIO, EDNEI LUIZ; MANCHINI, MARTHA TRINDADE; AUGUSTO SILVA, JAIRO MONTEMOR; FERREIRA TUCCI, PAULO JOSE; NATHANSON, LUBOV; MORRIS, MARIANA; et al. Photobiomodulation Therapy on Myocardial Infarction in Rats: Transcriptional and Posttranscriptional Implications to Cardiac Remodeling. Lasers in Surgery and Medicine, APR 2021. (12/15808-0, 09/54225-8, 15/11028-9)

VIEIRA, STELLA SOUZA; ANTONIO, EDNEI LUIZ; DE MELO, BRUNNO LEMES; NEVES DOS SANTOS, LUIS FELIPE; SANTANA, EDUARDO TADEU; FELICIANO, REGIANE; NAVARRO MARQUES, FABIO LUIZ; FARIA, DANIELE DE PAULA; BUCHPIGUEL, CARLOS ALBERTO; SILVA JR, JOSE ANTONIO; et al. Increased Myocardial Retention of Mesenchymal Stem Cells Post-MI by Pre-Conditioning Exercise Training. STEM CELL REVIEWS AND REPORTS, v. 16, n. 4, APR 2020. (09/54225-8, 18/06865-7, 15/11028-9)

SANTANA, EDUARDO T.; FELICIANO, REGIANE DOS SANTOS; SERRA, ANDREY J.; BRIGIDIO, EDUARDO; ANTONIO, EDNEI L.; TUCCI, PAULO J. F.; NATHANSON, LUBOV; MORRIS, MARIANA; SILVA, JR., JOSE A.. Comparative mRNA and MicroRNA Profiling during Acute Myocardial Infarction Induced by Coronary Occlusion and Ablation Radio-Frequency Currents. FRONTIERS IN PHYSIOLOGY, v. 7, NOV 25 2016. (15/11028-9, 12/15808-0, 09/54225-8)

DE MELO, BRUNNO LEMES; VIEIRA, STELLA S.; ANTONIO, EDNEI L.; DOS SANTOS, LUIS F. N.; PORTES, LESLIE A.; FELICIANO, REGIANE S.; DE OLIVEIRA, HELENITA A.; SILVA, JR., JOSE A.; DE CARVALHO, PAULO DE TARSO C.; TUCCI, PAULO J. F.; et al. Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis. FRONTIERS IN PHYSIOLOGY, v. 7, DEC 5 2016. (15/11028-9)

DE OLIVEIRA, HELENITA ANTONIA; ANTONIO, EDNEI LUIZ; SILVA, FLAVIO ANDRE; CAMILLO DE CARVALHO, PAULO DE TARSO; FELICIANO, REGIANE; YOSHIZAKI, AMANDA; VIEIRA, STELLA DE SOUZA; DE MELO, BRUNNO LEMES; PINTO LEAL-JUNIOR, ERNESTO CESAR; LABAT, RODRIGO; et al. Protective effects of photobiomodulation against resistance exercise-induced muscle damage and inflammation in rats. JOURNAL OF SPORTS SCIENCES, v. 36, n. 20, p. 2349-2357, 2018. (15/11028-9)

MANCHINI, MARTHA T.; ANTONIO, EDNEI L.; SILVA JUNIOR, JOSE ANTONIO; DE CARVALHO, PAULO DE TARSO C.; ALBERTINI, REGIANE; PEREIRA, FERNANDO C.; FELICIANO, REGIANE; MONTEMOR, JAIRO; VIEIRA, STELLA S.; GRANDINETTI, VANESSA; et al. Low-Level Laser Application in the Early Myocardial Infarction Stage Has No Beneficial Role in Heart Failure. FRONTIERS IN PHYSIOLOGY, v. 8, JAN 30 2017. (15/11028-9)

VIEIRA, STELLA SOUZA; ANTONIO, EDNEI LUIZ; DE MELO, BRUNNO LEMES; NEVES DOS SANTOS, LUIS FELIPE; SANTANA, EDUARDO TADEU; FELICIANO, REGIANE; NAVARRO MARQUES, FABIO LUIZ; FARIA, DANIELE DE PAULA; BUCHPIGUEL, CARLOS ALBERTO; SILVA JR, JOSE ANTONIO; et al. Increased Myocardial Retention of Mesenchymal Stem Cells Post-MI by Pre-Conditioning Exercise Training. STEM CELL REVIEWS AND REPORTS, v. 16, n. 4, p. 12-pg., 2020-04-18. (18/06865-7, 09/54225-8, 15/11028-9)

DOS SANTOS, SOLANGE ALMEIDA; SERRA, ANDREY JORGE; STANCKER, TATIANE GARCIA; BRANDAO SIMOES, MAIRA CECILIA; DOS SANTOS VIEIRA, MARCIA ATAIZE; LEAL-JUNIOR, ERNESTO CESAR; PROKIC, MARKO; VASCONSUELO, ANDREA; SANTOS, SIMONE SILVA; CAMILLO DE CARVALHO, PAULO DE TARSO. Effects of Photobiomodulation Therapy on Oxidative Stress in Muscle Injury Animal Models: A Systematic Review. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2017, p. 8-pg., 2017-01-01. (15/13677-4, 15/11028-9)

FELICIANO, REGIANE SANTOS; MANCHINI, MARTHA T.; SANTANA, EDUARDO T.; MARETTI, JOAO V.; CAPRONI, LARISSA I.; ANTONIO, EDNEI; SERRA, ANDREY J.; TUCCI, PAULO J.; SILVA, JOSE A., JR.. Lasertherapy after induction of myocardial infarction by coronary artery occlusion in rats: a genetic signature. FASEB JOURNAL, v. 31, p. 1-pg., 2017-04-01. (12/15808-0, 15/11028-9, 09/54225-8)

DE OLIVEIRA, HELENITA ANTONIA; ANTONIO, EDNEI LUIZ; ARSA, GISELA; SANTANA, EDUARDO TADEU; SILVA, FLAVIO ANDRE; ARRUDA JUNIOR, DANIEL; DOS SANTOS, SIMONE; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR; ARAUJO, AMANDA; et al. Photobiomodulation Leads to Reduced Oxidative Stress in Rats Submitted to High-Intensity Resistive Exercise. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018. (15/11028-9, 17/09274-7)

ARSA, GISELA; LANZA, FERNANDA CORDOBA; CAMBRI, LUCIELI TERESA; ANTONIO, EDNEI LUIZ; MURAD, NEIF; DE MELLO, MARCO TULIO; SANTOS, ALEXANDRA ALBERTO; CAMILLO DE CARVALHO, PAULO DE TARSO; SILVA-JUNIOR, JOSE ANTONIO; BOCALINI, DANILO SALES; et al. Predicted Equation for VO2 Based on a 20-Meter Multistage Shuttle Run Test for Children. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 39, n. 14, p. 1049-1054, DEC 2018. (15/11028-9)

VIEIRA, STELLA DE SOUZA; ANTONIO, EDNEI LUIZ; DE MELO, BRUNNO LEMES; PORTES, LESLIE ANDREWS; MONTEMOR, JAIRO; OLIVEIRA, HELENITA ANTONIA; MARTINS, FLAVIA LETICIA; ZOGBI, CAMILA; GIRARDI, ADRIANA COSTA; SILVA, JR., JOSE ANTONIO; et al. Exercise Training Potentiates The Cardioprotective Effects of Stem Cells Post-infarction. HEART LUNG AND CIRCULATION, v. 28, n. 2, p. 263-271, FEB 2019. (15/11028-9, 13/10619-8)

SERRA, ANDREY JORGE; PROKIC, MARKO D.; VASCONSUELO, ANDREA; PINTO, JOSE RENATO. Oxidative Stress in Muscle Diseases: Current and Future Therapy. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2018, p. 4-pg., 2018-01-01. (17/09274-7, 15/11028-9)

DE OLIVEIRA, HELENITA ANTONIA; ANTONIO, EDNEI LUIZ; ARSA, GISELA; SANTANA, EDUARDO TADEU; SILVA, FLAVIO ANDRE; ARRUDA JUNIOR, DANIEL; DOS SANTOS, SIMONE; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR; ARAUJO, AMANDA; et al. Photobiomodulation Leads to Reduced Oxidative Stress in Rats Submitted to High-Intensity Resistive Exercise. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2018, p. 9-pg., 2018-01-01. (17/09274-7, 15/11028-9)

REIS JUNIOR, DERMEVAL; ANTONIO, EDNEI LUIZ; DE FRANCO, MARCELLO FABIANO; DE OLIVEIRA, HELENITA ANTONIA; FERREIRA TUCCI, PAULO JOSE; SERRA, ANDREY JORGE. Association of Exercise Training with Tobacco Smoking Prevents Fibrosis but has Adverse Impact on Myocardial Mechanics. NICOTINE & TOBACCO RESEARCH, v. 18, n. 12, p. 2268-2272, DEC 2016. (15/11028-9, 09/54225-8)

DA SILVA, MARIANA MOREIRA; ALBERTINI, REGIANE; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR; BUSSADORI, SANDRA KALIL; VIEIRA, STELLA SOUSA; BOCALINI, DANILO SALES; FRANCO DE OLIVEIRA, LUIS VICENTE; GRANDINETTI, VANESSA; SILVA, JR., JOSE ANTONIO; et al. Randomized, blinded, controlled trial on effectiveness of photobiomodulation therapy and exercise training in the fibromyalgia treatment. Lasers in Medical Science, v. 33, n. 2, p. 343-351, FEB 2018. (15/11028-9)

YOSHIZAKI, AMANDA; ANTONIO, EDNEI LUIZ; SILVA JUNIOR, JOSE ANTONIO; CRAJOINAS, RENATO OLIVEIRA; SILVA, FLAVIO ANDRE; COSTA GIRARDI, ADRIANA CASTELLO; BOCALINI, DANILO SALES; PORTES, LESLIE ANDREWS; NEVES DOS SANTOS, LUIS FELIPE; CARLOS, FERNANDO PEREIRA; et al. Swimming Training Improves Myocardial Mechanics, Prevents Fibrosis, and Alters Expression of Ca2+ Handling Proteins in Older Rats. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v. 73, n. 4, p. 468-474, APR 2018. (13/10619-8, 15/11028-9)

GRANDINETTI, VANESSA; CARLOS, FERNANDO P. EREIRA; ANTONIO, EDNEI LUIZ; DE OLIVEIRA, HELENITA ANTONIA; NEVES DOS SANTOS, LUIS FELIPE; YOSHIZAKI, AMANDA; DIAS MARTINS MANSANO, BARBARA SAMPAIO; SILVA, FLAVIO ANDRE; PORTE, LESLIE ANDREWS; ALBUQUERQUE-PONTES, GIANNA MOES; et al. Photobiomodulation therapy combined with carvedilol attenuates post-infarction heart failure by suppressing excessive inflammation and oxidative stress in rats. SCIENTIFIC REPORTS, v. 9, JUL 1 2019. (18/06865-7, 15/11028-9)

LEVY, R. F.; SERRA, A. J.; ANTONIO, E. L.; DOS SANTOS, L.; BOCALINI, D. S.; PESQUERO, J. B.; BADER, M.; MERINO, V. F.; DE OLIVEIRA, H. A.; DE ARRUDA VEIGA, E. C.; et al. Cardiac Morphofunctional Characteristics of Transgenic Rats With Overexpression of the Bradykinin B1 Receptor in the Endothelium. Physiological Research, v. 66, n. 6, p. 925-932, 2017. (09/54225-8, 15/11028-9)

FELICIANO, REGIANE DOS SANTOS; BARBOZA ATUM, ALLAN LUIS; DA SILVA RUIZ, ERICO GUSTAVO; SERRA, ANDREY JORGE; ANTONIO, EDNEI LUIZ; MANCHINI, MARTHA TRINDADE; AUGUSTO SILVA, JAIRO MONTEMOR; FERREIRA TUCCI, PAULO JOSE; NATHANSON, LUBOV; MORRIS, MARIANA; et al. Photobiomodulation Therapy on Myocardial Infarction in Rats: Transcriptional and Posttranscriptional Implications to Cardiac Remodeling. Lasers in Surgery and Medicine, v. 53, n. 9, p. 1247-1257, NOV 2021. (09/54225-8, 12/15808-0, 15/11028-9)