Thermal analysis applied to drugs: antidepressants

• Grant number: 15/09299-4
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2015
• End date: November 30, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Éder Tadeu Gomes Cavalheiro
• Grantee: Éder Tadeu Gomes Cavalheiro
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

Considering the potentialities of the use of thermal methods in the characterization, evaluation of thermal stability and drug degradation mechanisms, this project has as main objective to contribute with the development of such studies.The thermal methods can provide important information about stability, durability and physicochemical parameters of storage of drugs and their formulations as well as informations on the mechanisms and waste decomposition. Chromatographic procedures will be used in the separation and characterization of the solid wastes, while FTIR coupled to TG will be used in the volatiles characterization.We should consider also that the drugs are becoming important environmental contamination agents, for domestic and industrial effluents, which requires understanding of their mechanisms of decomposition, including the volatile and waste degradation at different temperatures. Thermal decomposition studies can guide in the alternative proposition for remediation processes, in the case of environmental contamination by drugs and their formulations, as well as in the elimination of material with validity expired or problematic lots.So, it is believed that the project must present embracing results in different fronts of research in the thermal analysis. Preliminary results obtained and presented in the literature and in scientific congresses, point to high possibility of success in the realization of the proposal and in the fulfillment of its objectives and demonstrate the capacity of the proponent group to conduct such studies. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE JESUS, J. H. F.; SOUZA, M. S.; ELLENA, J. A.; CAVALHEIRO, E. T. G.. Thermal behavior of inosine 5 '-monophosphate complexes with cobalt(II), nickel(II), copper(II) and cadmium(II) cations. Thermochimica Acta, v. 680, p. 7-pg., 2019-10-01. (15/09299-4)

JESUS, J. H. F. DE; FERREIRA, A. P. G.; SZILAGYI, I. M.; CAVALHEIRO, E. T. G.. Thermal behavior and polymorphism of the antioxidants: BHA, BHT and TBHQ. FUEL, v. 278, OCT 15 2020. (15/09299-4)

BACCARIN, MARINA; CERVINI, PRISCILA; GOMES CAVALHEIRO, EDER TADEU. Comparative performances of a bare graphite-polyurethane composite electrode unmodified and modified with graphene and carbon nanotubes in the electrochemical determination of escitalopram. Talanta, v. 178, p. 1024-1032, FEB 1 2018. (15/09299-4)

DE ARAUJO, ELIENE LEANDRO; GONCALVES BARBOSA, HELLEN FRANCIANE; DOCKAL, EDWARD RALPH; GOMES CAVALHEIRO, EDER TADEU. Synthesis, characterization and biological activity of Cu(II), Ni(II) and Zn(II) complexes of biopolymeric Schiff bases of salicylaldehydes and chitosan. International Journal of Biological Macromolecules, v. 95, p. 168-176, FEB 2017. (15/09299-4)

DE JESUS, J. H. F.; SOUZA, M. S.; ELLENA, J. A.; CAVALHEIRO, E. T. G.. Thermal behavior of inosine 5 `-monophosphate complexes with cobalt(II), nickel(II), copper(II) and cadmium(II) cations. Thermochimica Acta, v. 680, OCT 2019. (15/09299-4)

DE JESUS, J. H. F.; MEDEIROS, R. S.; ELLENA, J. A.; CAVALHEIRO, E. T. G.. Tert-butylhydroquinone: structural elucidation of a new polymorphic form. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 148, n. 1, p. 8-pg., 2022-10-03. (15/09299-4, 17/15850-0)

PINTO, B. V.; FERREIRA, A. P. G.; CAVALHEIRO, E. T. G.. Thermal degradation mechanism for citalopram and escitalopram. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 133, n. 3, p. 1509-1518, SEP 2018. (14/22142-4, 15/09299-4)

DE JESUS, JANY H. F.; CAVALHEIRO, EDER T. G.. THERMOANALYTICAL STUDIES ON NEW POLYMORPHIC FORMS OF PROPYL, OCTYL AND DODECYL GALLATES. Thermochimica Acta, v. 707, JAN 2022. (15/09299-4)

DE JESUS, J. H. F.; FERREIRA, A. P. G.; CAVALHEIRO, E. T. G.. Thermal behavior of inosine 5'-monophosphate in acidic form and as alkali and alkaline earth salts. Food Chemistry, v. 258, p. 199-205, AUG 30 2018. (15/09299-4)

FERREIRA, A. P. G.; PINTO, V, B.; CAVALHEIRO, E. T. G.. Thermal decomposition investigation of paroxetine and sertraline. JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS, v. 136, p. 232-241, NOV 2018. (14/22142-4, 15/09299-4)

DE JESUS, J. H. F.; SZILAGYI, I. M.; REGDON, G., JR.; CAVALHEIRO, E. T. G.. Thermal behavior of food preservative sorbic acid and its derivates. Food Chemistry, v. 337, p. 9-pg., 2021-02-01. (15/09299-4)