Evaluation of myocardial fibrosis by cardiac magnetic resonance in risk stratification in Chagas' Disease

• Grant number: 14/17643-4
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2015
• End date: December 31, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Carlos Eduardo Rochitte
• Grantee: Carlos Eduardo Rochitte
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Barbara Maria Ianni ; Charles Mady ; Martino Martinelli Filho ; Tiago Senra Garcia dos Santos

Abstract

This is a retrospective study including 100 individuals with a positive Chagas´ Disease serology previously submitted to Cardiac Magnetic Resonance (CMR) with myocardial fibrosis evaluation. Myocardial fibrosis will be qualitatively and quantitatively evaluated alog with several cardiac parameters such as: ventricular volumes, function and mass, cardiac chamber measurements and regional systolic dysfunction identified in tagging images. All participants´electronic and paper medical records will be reviewed in order to collect epidemiologic, echocardiographic, electrocardiographic and image data to calculate the Rassi Risk Score. Hard events such as death, reversed sudden death, heart transplantation and appropriate implantable cardiac defibrillator therapy data will be collected as well. The main goal of this study is to establish the prognostic value of myocardial fibrosis evaluated by CMR in this population. Our secondary goal is to determine if myocardial fibrosis constitutes an independent and additional risk factor compared to the Rassi Risk Score.As a substudy, we will correlate myocardial fibrosis with regional systolic dysfunction identified by tagging images. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SENRA, TIAGO; IANNI, BARBARA M.; COSTA, ANA C. P.; MADY, CHARLES; MARTINELLI-FILHO, MARTINO; KALIL-FILHO, ROBERTO; ROCHITTE, CARLOS E.. Long-Term Prognostic Value of Myocardial Fibrosis in Patients With Chagas Cardiomyopathy. Journal of the American College of Cardiology, v. 72, n. 21, p. 2577-2587, NOV 27 2018. (14/17643-4)