Relationship between visceral, hepatic and bone adiposity with bone mineral density and fracture occurrence in type 1 Diabetes mellitus

• Grant number: 14/15864-3
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2015
• End date: November 30, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Francisco José Albuquerque de Paula
• Grantee: Francisco José Albuquerque de Paula
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Bone has long been thought of purely in its structural context. Likewise, adipose tissue had been considered a metabolically inert tissue without influence on body energy utilization. Currently, evidences have revealed an important interactive role between bone and adipose tissue in the regulation of energy and mineral metabolism. Consequently, a great interest emerged in the investigation about the metabolic network involving bone and adipose tissue and on the association between diabetes mellitus (DM) and osteoporosis. The interplay between adipose tissue and bone occurs, in part, by leptin action. This adipokine secreted by adipose tissue has central and peripheral action on osteoblasts, inhibiting or stimulating bone formation, respectively. Additionally, osteocalcin, a peptide synthesized by osteoblasts, is able to stimulate both, insulin sensitivity and insulin secretion. In parallel, recent studies had demonstrated that insulin acts on osteoblasts, through binding to its receptors on the surface of osteoblasts cells, promoting bone formation. Another important aspect is that osteoblasts and bone marrow adipocytes share a common mesenchymal cell progenitor. Accordingly, the aim of this study is to assess quality and quantity of bone mass and relationship between bone and energy metabolism in patients with type 1 DM (T1DM), T1DM patients underwent hematopoietic stem cells transplantation (HSCT) and non-diabetic subjects. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PARREIRAS-E-SILVA, LUCIANA T.; DE ARAUJO, IANA M.; ELIAS, JORGE, JR.; NOGUEIRA-BARBOSA, MARCELLO H.; SUEN, VIVIAN M. M.; MARCHINI, JULIO S.; BONELLA, JESSICA; NAHAS, ANDRESSA K.; SALMON, CARLOS E. G.; DE PAULA, FRANCISCO J. A.. Short bowel syndrome: influence of nutritional therapy and incretin GLP1 on bone marrow adipose tissue. Annals of the New York Academy of Sciences, v. 1415, n. 1, p. 10-pg., 2018-03-01. (16/18574-1, 14/15864-3)

PARREIRAS-E-SILVA, LUCIANA T.; DE ARAUJO, IANA M.; ELIAS, JR., JORGE; NOGUEIRA-BARBOSA, MARCELLO H.; SUEN, VIVIAN M. M.; MARCHINI, JULIO S.; BONELLA, JESSICA; NAHAS, ANDRESSA K.; SALMON, CARLOS E. G.; DE PAULA, FRANCISCO J. A.. Short bowel syndrome: influence of nutritional therapy and incretin GLP1 on bone marrow adipose tissue. Annals of the New York Academy of Sciences, v. 1415, n. 1, SI, p. 47-56, MAR 2018. (14/15864-3, 16/18574-1)

ALBUQUERQUE DE PAULA, FRANCISCO JOSE; ROSEN, CLIFFORD J.. Structure and Function of Bone Marrow Adipocytes. COMPREHENSIVE PHYSIOLOGY, v. 8, n. 1, p. 315-349, JAN 2018. (14/15864-3)

CARVALHO, ADRIANA L.; MASSARO, BIANCA; E SILVA, LUCIANA T. P.; SALMON, CARLOS E. G.; FUKADA, SANDRA Y.; NOGUEIRA-BARBOSA, MARCELLO H.; ELIAS, JR., JORGE; FREITAS, MARIA C. F.; COURI, CARLOS E. B.; OLIVEIRA, MARIA C.; et al. Emerging Aspects of the Body Composition, Bone Marrow Adipose Tissue and Skeletal Phenotypes in Type 1 Diabetes Mellitus. JOURNAL OF CLINICAL DENSITOMETRY, v. 22, n. 3, p. 420-428, JUL-SEP 2019. (15/09034-0, 14/14505-0, 14/15864-3, 13/09853-6)

CARVALHO, ADRIANA LELIS; DEMAMBRO, VICTORIA E.; GUNTUR, ANYONYA R.; LE, PHUONG; NAGANO, KENICHI; BARON, ROLAND; ALBUQUERQUE DE PAULA, FRANCISCO JOSE; MOTYL, KATHERINE J.. High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin-induced type 1 diabetic mice. Journal of Cellular Physiology, v. 233, n. 2, p. 1585-1600, FEB 2018. (14/14505-0, 14/15864-3, 13/09853-6)