| Grant number: | 15/25367-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | April 01, 2016 |
| End date: | March 31, 2018 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine |
| Principal Investigator: | Helena Beatriz de Carvalho Ruthner Batista |
| Grantee: | Helena Beatriz de Carvalho Ruthner Batista |
| Host Institution: | Instituto Pasteur (IP). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Associated researchers: | Ana Claudia Franco ; Henrique Ortêncio Filho ; Paulo Michel Roehe |
Abstract
Bats are mammals members of the order Chiroptera, widely distributed in the world. Despite the prominent role of bats in the ecological balance, the importance of these mammals as a source of infection of different infectious agents, particularly viruses, is a concern for Public Health. The first papers that described the interaction between bats and viruses were mainly focused on rabies virus (RABV) and other lyssavirus related, but it is known that these mammals may harbor other viruses. To date some 70 species of virus were identified in several species of bats worldwide. Some of these viruses are known to be agents of important human and animal diseases. Studies in Brazil mainly describe the different interactions that occur between bats and RABV. Detection of other viruses, a part of RABV, is still performed sporadically in Brazil. These studies were performed using the PCR or RT-PCR that identify each specific virus, but a new molecular biology tool has been used for detection of different infectious agents in various types of biological samples. This tool, called metagenomic allows more comprehensive detection genomes of viruses, bacteria and other known and unknown agents, whether for in vitro cultivation of necessity, allowing the detection of a very wide range of viruses and other agents, pathogenic or not, and with the ability to determine the full microbiome of different species. In Brazil, until the present it was not used this tool for this purpose. This project proposes the detection and identification of virus genomes in respiratory tract of different species of free-living bats and specimens sent for rabies diagnosis at the Pasteur Institute. For this purpose, it will be used metagenomics, which will allow the exploration of all virome present in the respiratory system of the examined species. (AU)
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