The impact of natural compounds in bacteria of clinical interest

• Grant number: 15/14278-6
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2016
• End date: September 30, 2018
• Field of knowledge: Biological Sciences - Microbiology
• Principal Investigator: Ary Fernandes Júnior
• Grantee: Ary Fernandes Júnior
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Lidiane Nunes Barbosa

Abstract

The widespread use of antimicrobial drugs has contributed to the emergence of microorganisms resistant to conventional drugs and comprising a public health problem worldwide because infections caused by micro-organisms resulting in increased mortality and morbidity populations. Investigations for new antimicrobial agents which are effective and less susceptible to bacterial resistance as compounds originating from plants, bacteriocins and antimicrobial peptides apply this demand. Establish an antimicrobial mechanism by which gives the action of a particular product is extremely complex due to a multitude of possibilities of action in the constitution and in the bacterial metabolism. Many tools can be used jointly to elucidate the antimicrobial activity of natural compounds such as, for example, electronic microscopy, membrane permeability analysis, genomics, flow cytometry and proteomic analysis. The aim of this project is to advance the knowledge of the antibacterial action of natural compounds such as essential oils, bacteriocins and bee products, in order to combat major pathogenic bacteria causing infectious diseases, many of them resistant to conventional drugs. Thereby elucidating the impact that these natural compounds cause in bacterial cells. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FURTADO, FABIANA BARCELOS; BORGES, BRUNA CRISTINA; TEIXEIRA, THAISE LARA; GARCES, HANS GARCIA; DE ALMEIDA JUNIOR, LUIZ DOMINGUES; BERGAMO ALVES, FERNANDA CRISTINA; DA SILVA, CLAUDIO VIEIRA; FERNANDES JUNIOR, ARY. Chemical Composition and Bioactivity of Essential Oil from Blepharocalyx salicifolius. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 1, JAN 2018. (15/14278-6)

MARQUES PEREIRA, ANA FLAVIA; ALBANO, MARIANA; BERGAMO ALVES, FERNANDA CRISTINA; MURBACH TELES ANDRADE, BRUNA FERNANDA; FURLANETTO, ALESSANDRA; MORES RALL, VERA LUCIA; DOS SANTOS, LUCILENE DELAZARI; ORSI, RICARDO DE OLIVEIRA; FERNANDES JUNIOR, ARY. Influence of apitoxin and melittin from Apis mellifera bee on Staphylococcus aureus strains. Microbial Pathogenesis, v. 141, APR 2020. (15/14278-6)

ALBANO, MARIANA; CRULHAS, BRUNO PEREIRA; BERGAMO ALVES, FERNANDA CRISTINA; MARQUES PEREIRA, ANA FLAVIA; MURBACH TELES ANDRADE, BRUNA FERNANDA; BARBOSA, LIDIANE NUNES; FURLANETTO, ALESSANDRA; DA SILVEIRA LYRA, LUCIANA PUPO; MORES RALL, VERA LUCIA; FERNANDES JUNIOR, ARY. Antibacterial and anti-biofilm activities of cinnamaldehyde against S. epidermidis. Microbial Pathogenesis, v. 126, p. 231-238, JAN 2019. (15/14278-6)

BERGAMO ALVES, FERNANDA CRISTINA; ALBANO, MARIANA; MURBACH TELES ANDRADE, BRUNA FERNANDA; CHECHI, JESSICA LUANA; MARQUES PEREIRA, ANA FLAVIA; FURLANETTO, ALESSANDRA; MORES RALL, VERA LUCIA; HENRIQUE FERNANDES, ANA ANGELICA; DOS SANTOS, LUCILENE DELAZARI; BARBOSA, LIDIANE NUNES; et al. Comparative Proteomics of Methicillin-Resistant Staphylococcus aureus Subjected to Synergistic Effects of the Lantibiotic Nisin and Oxacillin. MICROBIAL DRUG RESISTANCE, JUN 2019. (15/14278-6)

BARBOSA, LIDIANE NUNES; BERGAMO ALVES, FERNANDA CRISTINA; MURBACH TELES ANDRADE, BRUNA FERNANDA; ALBANO, MARIANA; MORES RALL, VERA LUCIA; HENRIQUE FERNANDES, ANA ANGELICA; RABELO BUZALAF, MARILIA AFONSO; LEITE, ALINE DE LIMA; DE PONTES, LETICIA GOMES; DOS SANTOS, LUCILENE DELAZARI; et al. Proteomic analysis and antibacterial resistance mechanisms of Salmonella Enteritidis submitted to the inhibitory effect of Origanum vulgare essential oil, thymol and carvacrol. JOURNAL OF PROTEOMICS, v. 214, MAR 1 2020. (15/14278-6)

BERGAMO ALVES, FERNANDA CRISTINA; ALBANO, MARIANA; MURBACH TELES ANDRADE, BRUNA FERNANDA; CHECHI, JESSICA LUANA; MARQUES PEREIRA, ANA FLAVIA; FURLANETTO, ALESSANDRA; MORES RALL, VERA LUCIA; HENRIQUE FERNANDES, ANA ANGELICA; DOS SANTOS, LUCILENE DELAZARI; BARBOSA, LIDIANE NUNES; et al. Comparative Proteomics of Methicillin-Resistant Staphylococcus aureus Subjected to Synergistic Effects of the Lantibiotic Nisin and Oxacillin. MICROBIAL DRUG RESISTANCE, v. 26, n. 3, p. 179-189, MAR 1 2020. (15/14278-6)

FURTADO, FABIANA BARCELOS; BORGES, BRUNA CRISTINA; TEIXEIRA, THAISE LARA; GARCES, HANS GARCIA; DE ALMEIDA JUNIOR, LUIZ DOMINGUES; BERGAMO ALVES, FERNANDA CRISTINA; DA SILVA, CLAUDIO VIEIRA; FERNANDES JUNIOR, ARY. Chemical Composition and Bioactivity of Essential Oil from Blepharocalyx salicifolius. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 1, p. 13-pg., 2018-01-01. (15/14278-6)