GENE EXPRESSION OF ANTI-CACHECTIC AND PRO-CACHECTIC INFLAMMATORY MARKERS IN PATIENTS WITH GASTRIC AND BILIOPANCREATIC CONFLUENCE CANCER

• Grant number: 15/17651-0
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2016
• End date: April 30, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Selma Freire de Carvalho
• Grantee: Selma Freire de Carvalho
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Ajith Kumar Sankarankutty ; José Sebastião dos Santos ; Marilia Cerqueira Leite Seelaender ; Sofia Miranda de Figueiredo Ribeiro ; Susana Merino

Abstract

The aim of this research is to quantify inflammatory cytokines and ZAG in peripheral blood, and to evaluate gene expression of anti-cachectic and pro-cachectic inflammatory cytokines, and proteins involved in lipid metabolisms in whole blood samples of patients with gastric and biliopancreatic confluence cancer. This cross-sectional study will be conducted on 32 adult patients, of both genders, with gastric (n=15) and pancreatic (n=17) cancer, and 15 healthy controls. Food intake and body composition of all volunteers were doing assessed. Questionnaires assessing fatigue and quality of life were applied in patients with cancer. The diagnosis of cachexia will be made based on pre-established criteria. Anti-cachectic and pro-cachectic inflammatory cytokines and the adipokine ZAG were doing measured in peripheral blood samples. Additionally, gene expression of inflammatory cytokines, ZAG and PPAR-gamma in whole blood will be performed. Statistical analysis will be performed using specific software. (AU)