Ecotoxicological study and environmental risk assessment of illicit drugs in marine ecosystems

• Grant number: 15/17329-0
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2016
• End date: October 31, 2018
• Field of knowledge: Biological Sciences - Pharmacology - Toxicology
• Principal Investigator: Camilo Dias Seabra Pereira
• Grantee: Camilo Dias Seabra Pereira
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
• Associated researchers: Denis Moledo de Souza Abessa ; Eduardo Alves de Almeida ; Julián Blasco Moreno ; Luciane Alves Maranho ; Maria Laura Martin Diaz ; Tomas Angel Del Valls Casillas ; Wagner Vilegas

Abstract

Illicit drugs have been considered as a growing social and public health problem worldwide. Millions of people have consumed these substances, which cocaine is among the most consumed one. The consumption and trafficking of cocaine in South America have become more prominent, particularly in Brazil. The main responsible for the discharge of emerging substances (such as illicit drugs) in the marine environment are the domestic wastewater through sewage outfalls. Based on past studies of our group that identified the presence of cocaine in surface water at the Bay of Santos and biological effects in environmentally relevant concentrations, it comes the need for the environmental risk of illicit drugs in coastal environments through a tiered methodology which contemplates quantification in environmental matrices (surface water and bioaccumulation in marine organisms) and ecotoxicological study using as a model a marine organism sentinel (Perna perna mussels). This proposal is concerning the first study on illicit drug concentrations in a subtropical marine ecosystem and also the first assessment of possible adverse effects caused by illegal drugs to marine biota, in Brazil and in the world. To achieve this goal, we proposed the quantification of cocaine in environmental samples in the laboratory, as well as evaluating the acute and chronic toxicity of crack cocaine in Perna perna mussels. This proposal aims to contribute to information about the biological effects to draw attention to this type of contamination, and to propose tools for future application in biomonitoring and environmental legislation. (AU)

Scientific publications

(12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARBOSA ORTEGA, ANDRESSA DOS SANTOS; MARANHO, LUCIANE ALVES; NOBRE, CAIO RODRIGUES; MORENO, BEATRIZ BARBOSA; GUIMARAES, RAFAEL SOLE; LEBRE, DANIEL TEMPONI; DE SOUZA ABESSA, DENIS MOLEDO; RIBEIRO, DANIEL ARAKI; SEABRA PEREIRA, CAMILO DIAS. Detoxification, oxidative stress, and cytogenotoxicity of crack cocaine in the brown mussel Perna perna. Environmental Science and Pollution Research, v. 26, n. 27, SI, p. 27569-27578, SEP 2019. (15/17329-0)

FONTES, MAYANA KAROLINE; DE CAMPOS, BRUNO GALVAO; CORTEZ, FERNANDO SANZI; PUSCEDDU, FABIO HERMES; MORENO, BEATRIZ BARBOSA; MARANHO, LUCIANE ALVES; LEBRE, DANIEL TEMPONI; GUIMARAES, LUCIANA LOPES; SEABRA PEREIRA, CAMILO DIAS. Seasonal monitoring of cocaine and benzoylecgonine in a subtropical coastal zone (Santos Bay, Brazil). Marine Pollution Bulletin, v. 149, DEC 2019. (16/24033-3, 15/17329-0)

FONTES, MAYANA KAROLINE; DE CAMPOS, BRUNO GALVAO; CORTEZ, FERNANDO SANZI; PUSCEDDU, FABIO HERMES; NOBRE, CAIO RODRIGUES; MORENO, BEATRIZ BARBOSA; LEBRE, DANIEL TEMPONI; MARANHO, LUCIANE ALVES; SEABRA PEREIRA, CAMILO DIAS. Mussels get higher: A study on the occurrence of cocaine and benzoylecgonine in seawater, sediment and mussels from a subtropical ecosystem (Santos Bay, Brazil). Science of The Total Environment, v. 757, FEB 25 2021. (15/17329-0, 16/24033-3)

SOUZA, LORENA DA SILVA; PUSCEDDU, FABIO HERMES; CORTEZ, FERNANDO SANZI; DE ORTE, MANOELA ROMANO; SEABRA, ALESSANDRA ALOISE; CESAR, AUGUSTO; RIBEIRO, DANIEL ARAKI; DEL VALLS CASILLAS, TOMAS ANGEL; SEABRA PEREIRA, CAMILO DIAS. Harmful effects of cocaine byproduct in the reproduction of sea urchin in different ocean acidification scenarios. Chemosphere, v. 236, DEC 2019. (18/18456-4, 14/22273-1, 15/17329-0)

FONTES, MAYANA KAROLINE; MARANHO, LUCIANE ALVES; PEREIRA, CAMILO DIAS SEABRA. Review on the occurrence and biological effects of illicit drugs in aquatic ecosystems. Environmental Science and Pollution Research, v. 27, n. 25, MAY 2020. (15/17329-0, 16/24033-3)

ROSATI, LUIGI; CAPUTO, IVANA; LIONETTI, LILLA; FONTES, MAYANA KAROLINE; PEREIRA, CAMILO DIAS SEABRA; CAPALDO, ANNA. Side Effects of Human Drug Use: An Overview of the Consequences of Eels' Exposure to Cocaine. FISHES, v. 8, n. 3, p. 18-pg., 2023-03-01. (15/17329-0, 19/20187-4, 16/24033-3)

FONTES, MAYANA KAROLINE; DOURADO, PRISCILA LEOCADIO ROSA; CAMPOS, BRUNO GALVA DE; MARANHO, LUCIANE ALVES; ALMEIDA, EDUARDO ALVES DE; ABESSA, DENIS MOLEDO DE SOUZA; PEREIRA, CAMILO DIAS SEABRA. Environmentally realistic concentrations of cocaine in seawater disturbed neuroendrocrine parameters and energy status in the marine mussel Perna perna. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v. 251, JAN 2022. (16/24033-3, 15/17329-0)

BARBOSA ORTEGA, ANDRESSA DOS SANTOS; MARANHO, LUCIANE ALVES; NOBRE, CAIO RODRIGUES; MORENO, BEATRIZ BARBOSA; GUIMARAES, RAFAEL SOLE; LEBRE, DANIEL TEMPONI; DE SOUZA ABESSA, DENIS MOLEDO; RIBEIRO, DANIEL ARAKI; SEABRA PEREIRA, CAMILO DIAS. Detoxification, oxidative stress, and cytogenotoxicity of crack cocaine in the brown mussel Perna perna. Environmental Science and Pollution Research, v. 26, n. 27, p. 10-pg., 2019-09-01. (15/17329-0)

FONTES, MAYANA KAROLINE; ROSATI, LUIGI; DI LORENZO, MARIANA; SEABRA PEREIRA, CAMILO DIAS; MARANHO, LUCIANE ALVES; LAFORGIA, VINCENZA; CAPALDO, ANNA. Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries of Anguilla anguilla. ANIMALS, v. 12, n. 14, p. 15-pg., 2022-07-01. (15/17329-0, 16/24033-3, 19/20187-4)

MARANHO, L. A.; FONTES, M. K.; KAMIMURA, A. S. S.; NOBRE, C. R.; MORENO, B. B.; PUSCEDDU, F. H.; CORTEZ, F. S.; LEBRE, D. T.; MARQUES, J. R.; ABESSA, D. M. S.; et al. Exposure to crack cocaine causes adverse effects on marine mussels Perna perna. Marine Pollution Bulletin, v. 123, n. 1-2, p. 410-414, OCT 15 2017. (15/17329-0)

PASSARELLI, MARINA CUNHA; BONNAIL, ESTEFANIA; CESAR, AUGUSTO; RIBA, INMACULADA. Risk Assessment of a Coastal Ecosystem from SW Spain Exposed to CO2 Enrichment Conditions. APPLIED SCIENCES-BASEL, v. 13, n. 9, p. 15-pg., 2023-05-08. (15/17329-0, 18/18456-4, 17/25936-0)

SOUZA, LORENA DA SILVA; BONNAIL, ESTEFANIA; DE ALMEIDA DUARTE, LUIS FELIPE; CESAR, AUGUSTO; RIBA, INMACULADA; PEREIRA, CAMILO DIAS SEABRA. Integrated Assessment of CO2-Induced Acidification Lethal and Sub-Lethal Effects on Tropical Mussels Perna perna. APPLIED SCIENCES-BASEL, v. 13, n. 12, p. 13-pg., 2023-06-01. (15/17329-0, 18/18456-4)