SYNTHESIS, CHARACTERIZATION AND BIOCOMPATIBILITY EVALUATION OF BIOCERAMIC SCAFFOLDS PREPARED BY FREEZE CASTING METHOD

• Grant number: 15/24659-7
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2016
• End date: May 31, 2018
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Eliandra de Sousa Trichês
• Grantee: Eliandra de Sousa Trichês
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
• Associated researchers: Mariana Motisuke ; Samira Esteves Afonso Camargo

Abstract

Scaffolds' research and its production have been receiving a high importance for tissue engineering in the past few years. They can be defined as supports that serve as substrate for cellular differentiation, proliferation and growth. Thus, they must be biocompatible; show great porosity and interconnectivity; have optimal degradation rates, geometry and pore size; besides of a favourable biological and mechanical properties. Bioceramics of calcium phosphate have been considered to produce scaffolds for bone treatments due to their reabsorption rate, morphology and chemical composition similar to the bone mineral phase. One of the techniques to obtain bioceramic scaffolds is freeze casting which has been outstanding for its versatility to control the porosity and morphology of the pores. In this method, a ceramic suspension (aqueous or not) is prepared, frozen, sublimated and then sintered, resulting in a porous ceramic body whose pores are basically a replica of the solvent crystals. However, the processing parameters still have to be analyzed in order to obtain good mechanical properties and appropriate porosity. The aim of this work is to produce bioceramic scaffolds by freeze casting method. The morphological, physical and mechanical properties will be determined aiming its future application in Tissue Engineering as scaffolds for bone tissue treatment. Biocompatibility studies and cell viability will be also evaluated. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE MOURA, NAYARA KOBA; MARTINS, EDUARDO FERREIRA; MORAES SALDANHA OLIVEIRA, RODRIGO LUIZ; WALTRICK DE BRITO SIQUEIRA, IDALIA APARECIDA; BARROS MACHADO, JOAO PAULO; ESPOSITO, ELISA; AMARAL, SUELEN SIMOES; REIS DE VASCONCELLOS, LUANA MAROTTA; PASSADOR, FABIO ROBERTO; TRICHES, ELIANDRA DE SOUSA. Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration. Materials Science & Engineering C-Materials for Biological Applications, v. 117, DEC 2020. (15/24659-7)

C. G. DE PAULA; E. S. TRICHÊS. Preparação e caracterização de scaffolds de β-fosfato tricálcico pelo método de freeze casting. Cerâmica, v. 64, n. 372, p. 553-558, 2018-12-00. (15/24659-7)

DE MOURA, NAYARA KOBA; SIQUEIRA, IDALIA A. W. B.; DE BARROS MACHADO, JOAO PAULO; KIDO, HUELITON WILIAN; AVANZI, INGRID REGINA; MUNIZ RENNO, ANA CLAUDIA; TRICHES, ELIANDRA DE SOUSA; PASSADOR, FABIO ROBERTO. Production and Characterization of Porous Polymeric Membranes of PLA/PCL Blends with the Addition of Hydroxyapatite. JOURNAL OF COMPOSITES SCIENCE, v. 3, n. 2, p. 14-pg., 2019-06-01. (15/24659-7, 16/19978-9)

SIQUEIRA, IDALIA A. W. B.; DE MOURA, NAYARA KOBA; DE BARROS MACHADO, JOAO PAULO; BACKES, EDUARDO HENRIQUE; PASSADOR, FABIO ROBERTO; TRICHES, ELIANDRA DE SOUSA. Porous membranes of the polycaprolactone (PCL) containing calcium silicate fibers for guided bone regeneration. Materials Letters, v. 206, p. 210-213, NOV 1 2017. (15/24659-7)

OLIVEIRA, RODRIGO L. M. S.; BARBOSA, LUCAS; HURTADO, CAROLINA R.; RAMOS, LUCAS DE P.; MONTANHEIRO, THAIS L. A.; OLIVEIRA, LUCIANE D.; TADA, DAYANE B.; TRICHES, ELIANDRA DE SOUSA. Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity. Journal of Biomedical Materials Research Part A, v. 108, n. 12, JUN 2020. (15/24659-7, 17/01697-6)

LILIAN DE SIQUEIRA; LILIANA GRENHO; MARIA H. FERNANDES; FERNANDO J. MONTEIRO; ELIANDRA S. TRICHÊS. 45S5 Bioglass-Derived Glass-Ceramic Scaffolds Containing Niobium Obtained by Gelcasting Method. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 24, n. 1, 2021-02-03. (15/24659-7)

WALTRICK BRITO SIQUEIRA, IDALIA APARECIDA; AMARAL, SUELEN SIMOES; DE MOURA, NAYARA KOBA; BARROS MACHADO, JOAO PAULO; BACKES, EDUARDO HENRIQUE; PASSADOR, FABIO ROBERTO; AFONSO CAMARGO, SAMIRA ESTEVES; REIS DE VASCONCELLOS, LUANA MAROTTA; TRICHES, ELIANDRA SOUSA. In vitro bioactivity and biological assays of porous membranes of the poly(lactic acid) containing calcium silicate fibers. POLYMER BULLETIN, v. 77, n. 10, NOV 2019. (15/24659-7)