Comparative analysis of the mechanisms involved in the regulation of blood pressure during acute physical exercise in adults and elderly, hypertensive and normotensive and individuals with different level of training status

• Grant number: 15/24847-8
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2016
• End date: July 31, 2018
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Anderson Saranz Zago
• Grantee: Anderson Saranz Zago
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil

Abstract

There are many mechanisms that contribute to the high incidence of hypertension (HT) including aging, arterial stiffness, humoral and neural factors and oxidative stress. However, regular physical exercise can contribute to regulate such mechanism involved in blood pressure control and vascular function. It has been observed that there are still a lack of studies that concurrently assess the humoral factors (nitric oxide, renin-angiotensin aldosterone system), oxidative stress, neural and structural factors (arterial stiffness) both at rest conditions, as while during the acute exercise session, in order to understand which mechanisms is more responsive in the face of such stimulation. Thus, the aim of this research project is compare the mechanisms involved in blood pressure control and vascular function in adults and elderly, hypertensive and normotensive and individuals with different levels of training status at rest and during acute physical exercise. Participants will performed the following assessments: blood pressure, maximal oxygen uptake, assessment of arterial stiffening, blood collection (12 hours of fast) and a second blood collection (only 2 hours of fast) in the baseline moment and after acute physical exercise performed at 50-60% of VO2max. The blood samples will be used for the analysis of oxidative stress, nitric oxide and renin-angiotensin system, lipid and glycemic profile. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, ROBERTA FERNANDA; LACCHINI, RICCARDO; PINHEIRO, LUCAS CEZAR; FEREZIN, LETICIA PERTICARRARA; TANUS-SANTOS, JOSE EDUARDO; LUIZON, MARCELO RIZZATTI; DIONISIO, THIAGO JOSE; SANTOS, CARLOS FERREIRA; REIA, THAIS AMANDA; JACOMINI, ANDRE MOURAO; et al. Association between endothelial nitric oxide synthase and the renin-angiotensin-aldosterone system polymorphisms, blood pressure and training status in normotensive/pre-hypertension and hypertensive older adults: a pilot study. CLINICAL AND EXPERIMENTAL HYPERTENSION, JUN 2021. (15/03965-2, 15/24847-8)

DA SILVA, ROBERTA FERNANDA; TRAPE, ATILA ALEXANDRE; REIA, THAIS AMANDA; LACCHINI, RICCARDO; OLIVEIRA-PAULA, GUSTAVO HENRIQUE; PINHEIRO, LUCAS CEZAR; TANUS-SANTOS, JOSE EDUARDO; JACOMINI, ANDRE MOURAO; BUENO JUNIOR, CARLOS ROBERTO; ZAGO, ANDERSON SARANZ. Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults. PLoS One, v. 13, n. 10, OCT 18 2018. (15/24847-8)

DA SILVA, ROBERTA FERNANDA; LACCHINI, RICCARDO; PINHEIRO, LUCAS CEZAR; DIONISIO, THIAGO JOSE; JACOMINI, ANDRE MOURAO; TANUS-SANTOS, JOSE EDUARDO; AMARAL, SANDRA LIA; SANTOS, CARLOS FERREIRA; ZAGO, ANDERSON SARANZ. Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v. 19, n. 2, JUN 20 2018. (15/24847-8, 15/03965-2)

JACOMINI, ANDRE M.; DIAS, DANIELLE DA SILVA; BRITO, JANAINA DE OLIVEIRA; DA SILVA, ROBERTA F.; MONTEIRO, HENRIQUE L.; LLESUY, SUSANA; DE ANGELIS, KATIA; AMARAL, SANDRA L.; ZAGO, ANDERSON S.. Influence of Estimated Training Status on Anti and Pro-Oxidant Activity, Nitrite Concentration, and Blood Pressure in Middle-Aged and Older Women. FRONTIERS IN PHYSIOLOGY, v. 8, MAR 7 2017. (13/13146-3, 15/24847-8)

DA SILVA, ROBERTA FERNANDA; LACCHINI, RICCARDO; PINHEIRO, LUCAS CEZAR; FEREZIN, LETICIA PERTICARRARA; TANUS-SANTOS, JOSE EDUARDO; LUIZON, MARCELO RIZZATTI; DIONISIO, THIAGO JOSE; SANTOS, CARLOS FERREIRA; REIA, THAIS AMANDA; JACOMINI, ANDRE MOURAO; et al. Association between endothelial nitric oxide synthase and the renin-angiotensin-aldosterone system polymorphisms, blood pressure and training status in normotensive/pre-hypertension and hypertensive older adults: a pilot study. CLINICAL AND EXPERIMENTAL HYPERTENSION, v. 43, n. 7, p. 661-670, OCT 3 2021. (15/24847-8, 15/03965-2)