COMBINED TRAINING ANSWERS ON INFLAMMATION, METABOLIC FACTORS AND SERUM, MOLECULAR AND IMAGE MARKERS RELATED TO BROWN ADIPOSE TISSUE AND BROWNING OF WHITE ADIPOSE TISSUE IN OVERWEIGHT MIDDLE-AGE TYPE 2 DIABETIC

• Grant number: 16/08751-3
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2016
• End date: September 30, 2018
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Claudia Regina Cavaglieri
• Grantee: Claudia Regina Cavaglieri
• Host Institution: Faculdade de Educação Física (FEF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Bruno Rodrigues ; Celso Darío Ramos ; Licio Augusto Velloso ; Mara Patricia Traina Chacon Mikahil

Abstract

The aim of this study will be to analyze the acute and chronic responses of combined training on inflammation, metabolic factors and image, serum and molecular markers related to brown adipose tissue (BAT) and browning of white adipose tissue (WAT) in type 2 diabetics. The sample will be composed of type 2 diabetic subjects, of both genders, aged between 40 and 60 years and body mass index (BMI) <35 kg / m², divided into control group (CG, n = 15) and combined training group (CT, n = 15). In the pre and post experimental period will be evaluated analyzes: functional (muscular strength, aerobic fitness and resting metabolic rate), body composition (plethysmography) biochemical (basic clinical, incretins, inflammatory and BAT and browning of WAT stimulants), image (Tomography Positron Emission coupled with computed tomography (PET-CT)) and molecular (gene related to morphology/functionality of subcutaneous fat cells). Serum analyzes of BAT and browning of WAT stimulants will also be accessed right after the first and last training session. The CT program will be composed of strength training (~ 30 min, 1-3 sets of 8 to 12 repetitions, 50-75% of 1RM, 1-1 min. and 30 sec. of interval) followed aerobic training (35 min. at 50-60% VO2max) in the same session, performed 3 times weekly for 16 weeks. It is expected that the CT program increases serum of BAT and browning of the WAT stimulants, associated with molecular changes in fat cells and improve of metabolic, inflammatory and body composition variables. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BONFANTE, IVAN LUIZ PADILHA; DUFT, RENATA GARBELLINI; MATEUS, KERYMA CHAVES DA SILVA; TROMBETA, JOICE CRISTINA DOS SANTOS; FINARDI, ENRICO ANTONIO RAUTENBERG; RAMKRAPES, ANA PAULA BOITO; BRUNELLI, DIEGO TREVISAN; MORI, MARCELO ALVES DA SILVA; CHACON-MIKAHIL, MARA PATRICIA TRAINA; VELLOSO, LICIO AUGUSTO; et al. Acute/Chronic Responses of Combined Training on Serum Pro-thermogenic/Anti-inflammatory Inducers and Its Relation With Fed and Fasting State in Overweight Type 2 Diabetic Individual. FRONTIERS IN PHYSIOLOGY, v. 12, JAN 20 2022. (16/08751-3)

PADILHA BONFANTE, IVAN LUIZ; MONFORT-PIRES, MILENA; DUFT, RENATA GARBELLINI; DA SILVA MATEUS, KERYMA CHAVES; DE LIMA JUNIOR, JOSE CARLOS; DOS SANTOS TROMBETA, JOICE CRISTINA; RAUTENBERG FINARDI, ENRICO ANTONIO; BRUNELLI, DIEGO TREVISAN; MORARI, JOSEANE; BARBOSA DE LIMA, JESSICA APARECIDA; et al. Combined training increases thermogenic fat activity in patients with overweight and type 2 diabetes. International Journal of Obesity, v. 46, n. 6, p. 10-pg., 2022-02-16. (16/08751-3)