Response of osteoarthritis biomarkers after a rehabilitation program

• Grant number: 15/50274-5
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2016
• End date: March 31, 2019
• Field of knowledge: Health Sciences - Medicine - Surgery
• Agreement: Ohio State University
• Principal Investigator: Mario Ferretti Filho
• Grantee: Mario Ferretti Filho
• Principal researcher abroad: Sudha Agarwal
• Institution abroad: Ohio State University, Columbus, United States
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

The aim of this study is to evaluate the serie concentration of HMGB1 in OÁ patients before and after rehabilitation program and to correlate the levels of this biomarker with the patients' functional capacity values. The hypothesis of this study is that, rehabilitation program attenuates inflammation systemically and locally in patients with knee osteoarthritis by suppressing the HMGB1 levels, and also that HMGB1 is a new biomarker of improvement outeomes of knee osteoarthritis. (AU)