Development of multifunctional hybrid nano matrix: use as intelligent systems for drug delivery and substrates for construction of (bio) electrochemical sensors

• Grant number: 16/12519-9
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2016
• End date: September 30, 2018
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Thiago da Cruz Canevari
• Grantee: Thiago da Cruz Canevari
• Host Institution: Escola de Engenharia (EE). Universidade Presbiteriana Mackenzie (UPM). São Paulo , SP, Brazil
• Associated researchers: Antonio Hortencio Munhoz Junior ; Leila Figueiredo de Miranda ; Miriam Oliveira Ribeiro

Abstract

This work describes the synthesis, characterization and application of multifunctional nanostructured matrix constituted for hybrids nanomaterials as nanoallotropes of carbon/ silicon cubic nanoparticles and magnetic nanoparticles of metallic oxide of MxOy types. This project is promising and will go to contribute significantly for treatment of many diseases that reach many people on the world due development of new nanomaterials that could be used as drugs delivers intelligent that will provide fast diagnostic, more efficient resulting in more efficient treatment. Also will be employed as platform for development electrochemical biosensors that are used for to realize a critic quality control of water and effluent sludge avoiding this source against potential type of contamination and developments many diseases. The hybrids nanomaterials nanoallotropes carbon/ nanocube of silicon will be constituted for polyhedral oligomeric silsesquioxane (POS), carbon nanoparticles as carbon quantum dots, Cdots, and graphene oxides types (oxidized and reduced). Furthermore, will be synthesized also magnetic nanoparticles of metallic oxide of MxOy type (M= Fe3+, Al3+ e Zn2+) that will be anchored on different hybrid matrix carbon/silicon. In a subsequent step, the multifunctional hybrid nanomatrizes can will be modified with organic conducting polymers, such as 4-polivinilpiridínio and octadecylamine, with purposes of promoting the emergence of new physicochemical properties with respect to electrochemical characteristics and also in relation to the intelligent delivery drugs. The textural and structural properties of nanostructured matrix will be studied using the physical adsorption techniques of N2 at 77K (BET surface area, distribution and pore volume), electron microscopy, high resolution transmission (HR-TEM), scanning electron microscopy (SEM) photoelectron spectroscopy X-ray (XPS), X-ray diffraction (XRD), Raman spectroscopy and nuclear magnetic resonance (NMR) 29Si, 13C, 1H and 27Al. The electrochemical properties of glassy carbon electrode modified with nanostructured matrix will be studied taking into account the electrooxidation of acyclovir drugs, Atelonol, Captopril, as well as the estriol endocrine disruptors, 17±-ethynylestradiol and bisphenol. For this, the cyclic voltammetry, square wave voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy are used. The study of hybrid nanomaterials modified as possible vectors for the transport of biologically active particles for drug delivery will be performed in vitro and in vivo study taking into account the toxicity and pharmacokinetics. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CANEVARI, THIAGO C.; CINCOTTO, FERNANDO H.; GOMES, DELMARCIO; LANDERS, RICHARD; TOMA, HENRIQUE E.. Magnetite Nanoparticles Bonded Carbon Quantum Dots Magnetically Confined onto Screen Printed Carbon Electrodes and their Performance as Electrochemical Sensor for NADH. Electroanalysis, v. 29, n. 8, p. 1968-1975, AUG 2017. (16/16565-5, 16/12519-9, 13/24725-4)

CANEVARI, THIAGO C.; ROSSI, V, MAURA; ALEXIOU, ANAMARIA D. P.. Development of an electrochemical sensor of endocrine disruptor bisphenol A by reduced graphene oxide for incorporation of spherical carbon nanoparticles. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 832, p. 24-30, JAN 1 2019. (16/12519-9)

CINCOTTO, FERNANDO H.; CARVALHO, DANIEL A. S.; CANEVARI, THIAGO C.; TOMA, HENRIQUE E.; FATIBELLO-FILHO, ORLANDO; MORAES, FERNANDO C.. A nano-magnetic electrochemical sensor for the determination of mood disorder related substances. RSC ADVANCES, v. 8, n. 25, p. 14040-14047, 2018. (16/12519-9, 16/12926-3, 16/16565-5, 13/24725-4, 11/13312-5)