Sero-surveillance tools for targeting Plasmodium vivax infections and monitoring malaria control and elimination efforts in Amazonian countries

• Grant number: 16/50108-0
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2016
• End date: December 31, 2020
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Agreement: EU-CELAC IG (former ERA.Net - LAC)
• Principal Investigator: Irene da Silva Soares
• Grantee: Irene da Silva Soares
• Principal researcher abroad: Alejandro Llanos-Cuentas
• Institution abroad: Universidad Peruana Cayetano Heredia, Peru
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

A consortium composed by Universidad Peruana Cayetano Heredia, Universidade de São Paulo, Istituto Superiore di Sanità, Université Catholique de Louvain and Medical Research Council Unit aims to contribute for malaria elimination in the Amazon Region. For this, standardized serosurveillance tools will be developed to accurately monitor short and long-term changes in the Plasmodium vivax transmission. Based on blood samples of Plasmodium vivax-infected individuals from large South American cohorts, parasite antigens will be identified to detect either recent (≤6 months) or later (6-24, months) exposure. During the antigen screening, several aspects of the immune response will be considered for the selection of the best antigen candidates such as immunogenicity, specificity, antigenic diversity, antibody longevity and statistical analyses. Once defined, they will be incorporated into standard (ELISA) and/or high-throughput platforms for the tools generation. Those tools will be further assessed regarding their potential for monitoring changes in the malaria transmission into Peruvian and Brazilian Amazon ecological settings. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, NATALIA S.; LIMA, NATHALIA F.; SULCZEWSKI, FERNANDO B.; SOARES, IRENE S.; FERREIRA, MARCELO U.; BOSCARDIN, SILVIA B.. Plasmodium vivax infection changes the peripheral immunoregulatory network: CD4 T follicular cells and B cells. European Journal of Immunology, v. N/A, p. 15-pg., 2023-05-24. (18/07142-9, 16/18740-9, 16/50108-0)

REGIART, MATIAS; GIMENEZ, ALBA MARINA; MARQUES, RODOLFO F.; SOARES, IRENE S.; BERTOTTI, MAURO. Microfluidic device based on electrodeposited Nanoporous Gold/Carbon Nanotubes for Plasmodium vivax detection. SENSORS AND ACTUATORS B-CHEMICAL, v. 340, AUG 1 2021. (16/50108-0, 19/06293-6, 18/08782-1)

FRANCA, ANA CAROLINE BARBOSA; FRANCOSO, KATIA SANCHES; MARQUES, RODOLFO FERREIRA; TROSSINI, GUSTAVO H. G.; GOMES, RENAN A.; POVOA, MARINETE M.; CUNHA, MARISTELA G.; SILVEIRA, EDUARDO L. V.; SOARES, IRENE S.. Antibodies Against the Plasmodium vivax Apical Membrane Antigen 1 From the Belem Strain Share Common Epitopes Among Other Worldwide Variants. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, MAR 16 2021. (12/13032-5, 16/50108-0)

PERROTTI, EDVIGE; L'EPISCOPIA, MARIANGELA; MENEGON, MICHELA; SOARES, IRENE S.; ROSAS-AGUIRRE, ANGEL; SPEYBROECK, NIKO; LLANOS-CUENTAS, ALEJANDRO; MENARD, DIDIER; FERREIRA, MARCELO URBANO; SEVERINI, CARLO. Reduced polymorphism of Plasmodium vivax early transcribed membrane protein (PvETRAMP) 11.2. PARASITES & VECTORS, v. 16, n. 1, p. 11-pg., 2023-07-17. (16/50108-0)