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Sero-surveillance tools for targeting Plasmodium vivax infections and monitoring malaria control and elimination efforts in Amazonian countries

Grant number: 16/50108-0
Support type:Regular Research Grants
Duration: October 01, 2016 - December 31, 2020
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Cooperation agreement: EU-CELAC IG (former ERA.Net - LAC)
Principal Investigator:Irene da Silva Soares
Grantee:Irene da Silva Soares
Principal investigator abroad: Alejandro Llanos-Cuentas
Institution abroad: Universidad Peruana Cayetano Heredia, Peru
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

A consortium composed by Universidad Peruana Cayetano Heredia, Universidade de São Paulo, Istituto Superiore di Sanità, Université Catholique de Louvain and Medical Research Council Unit aims to contribute for malaria elimination in the Amazon Region. For this, standardized serosurveillance tools will be developed to accurately monitor short and long-term changes in the Plasmodium vivax transmission. Based on blood samples of Plasmodium vivax-infected individuals from large South American cohorts, parasite antigens will be identified to detect either recent (≤6 months) or later (6-24, months) exposure. During the antigen screening, several aspects of the immune response will be considered for the selection of the best antigen candidates such as immunogenicity, specificity, antigenic diversity, antibody longevity and statistical analyses. Once defined, they will be incorporated into standard (ELISA) and/or high-throughput platforms for the tools generation. Those tools will be further assessed regarding their potential for monitoring changes in the malaria transmission into Peruvian and Brazilian Amazon ecological settings. (AU)