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Correlation with different clinical stages in patients with Parkinson's disease and neuropathic pain: validation of the Rotterdam Elderly Pain Observation Scale (REPOS)

Grant number: 15/50089-3
Support type:Regular Research Grants
Duration: October 01, 2016 - September 30, 2018
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: Erasmus Universiteit Rotterdam
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Lauro Wichert Ana
Grantee:Lauro Wichert Ana
Principal investigator abroad: Dick Tibboel
Institution abroad: Erasmus University Rotterdam (EUR), Netherlands
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/25987-2 - Evaluation of the density of presynaptic dopamine Tranporters in humans: development and evaluation of quantitation protocols based on the hybrid SPECT-CT technology using 99mTc-TRODAT-1, AP.R


Parkinson’s disease (PD) is a progressive degenerative disease that affects the substantia nigra compact as well as other regions of the brain and other organs. Pain is a distressing non-motor symptom experienced by up 85% of people with PD and is often not expressed being unidentified. The scale of observation of pain in the Elderly (RESET) is a range of observational pain differs from other scales, including adults and seniors with limited communication without needing to communicate verbally, not yet validated for the Portuguese language. We wish to know if the motor changes associated with PD may be hiding the manifestation of pain. Objectives: (a) to monitor, discuss and analyze the application of REPOS in elderly patients at Erasmus MC; (b) Validate the translation of REPOS; (c) application in patients with PD and neuropathic pain. Methodology: will be included 20 healthy volunteers matched with 20 patients with PD and 20 with Neuropathic Pain. Patients should be observed for 2 minutes, during consultation, physical and neurological examination. Prevalence and behaviors of co-occurrences will be analyzed and identified. Will apply to Numeric Rating Scale, and REPOS, will run in the Pain Clinic and Disease Clinic Extra Pyramidal HCFMRP-USP, providing better treatment for patients with Neuropathic Pain and PD. These bilateral missions will encourage meetings, trainings, presentations and publications. (AU)