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Influence of the incorporation of TiO2 nanotubes in a polycrystalline zirconia: synthesis of nanotube, surface characterization, biocompatibility and bond strength

Grant number: 15/25827-0
Support Opportunities:Regular Research Grants
Duration: December 01, 2016 - November 30, 2018
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Adilson Yoshio Furuse
Grantee:Adilson Yoshio Furuse
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated researchers:Ana Flávia Sanches Borges ; Paulo Noronha Lisboa Filho ; Rodrigo Cardoso de Oliveira


Despite numerous advantages such as high strength and biocompatibility, cementing zirconia is still critical. The present study will evaluate the influence of the infiltration of TiO2 nanotubes in the biocompatibility and the bond strength of a resin cement to zirconia. TiO2 nanotubes will be produced by alkaline synthesis and characterized by diffraction X-ray, MEV and TEM. Then, will be mixed with absolute ethanol (50 wt%) and applied on pre-sintered zirconia discs (IPS e.max ZirCAD). The ceramics will be sintered and surfaces will be characterized by confocal laser microscopy and scanning electron microscopy (SEM). The biocompatibility will be evaluated by cell culture, cell viability, MTT, Crystal Violet and SEM. The ceramics will be divided into three groups (n = 10): 1) with the application of nanotubes; 2) without the application of nanotubes; 3) with the application of nanotubes and Single Bond Universal adhesive. Dual resin cement discs (RelyX Ultimate) will also be evaluated (n = 10). For the bond strength four groups (n = 10) will be evaluated: 1) control - without application of TiO2 nanotubes; 2) with the application of TiO2 nanotubes; 3) without application of TiO2 nanotubes and roughening with 100¼m Al2O3 air abrasion; 4) with application of TiO2 nanotubes and roughening with 100¼m Al2O3 air abrasion. After sintering, an adhesive will be applied (Single Bond Universal) and four resin cement (RelyX Ultimate) cylinders with a diameter of 1.40 mm and 1 mm in height will be prepared and light cured for 20 s over each disk. The specimens will be submitted to microshear test and surfaces will be analyzed in a stereomicroscope to determine the type of failure involved. Data will be analyzed using One-way ANOVA and Tukey's HSD test (± = 5%). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, ANGELICA FELTRIN; DE LUCENA, FERNANDA SANDES; SANCHES BORGES, ANA FLAVIA; LISBOA-FILHO, PAULO NORONHA; FURUSE, ADILSON YOSHIO. Incorporation of TiO2 nanotubes in a polycrystalline zirconia: Synthesis of nanotubes, surface characterization, and bond strength. JOURNAL OF PROSTHETIC DENTISTRY, v. 120, n. 4, p. 589-595, . (15/25827-0)

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