Exposition of nursing Wistar rats to Tityus bahiensis scorpion venom: effects in the milk composition and in the levels of neurotransmitters and cytokines of mothers and offspring.

• Grant number: 16/10196-8
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2016
• End date: November 30, 2018
• Field of knowledge: Biological Sciences - Pharmacology - Toxicology
• Principal Investigator: Ana Leonor Abrahao Nencioni Soares
• Grantee: Ana Leonor Abrahao Nencioni Soares
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Ana Leticia Coronado Dorce ; Valquiria Abrão Coronado Dorce

Abstract

The scorpionism is considered a serious public health problem in Brazil and worldwide. According to the Notification Diseases Service (SINAN) in the Ministry of Health website, accidents with women in the fertile period represented over 40% of cases between the years 2007 to 2012. Thus, the possible sting of a pregnant woman or a lactating is large and the study of the possible consequences to the fetus or the newborn becomes extremely important.In previous studies we observed that the venom of Tityus bahiensis scorpion, when administered to rats during pregnancy or lactation, causes changes in physical, reflexological and behavioral development of offspring both in perinatal period and adulthood, as well as alterations in the level of some cytokines in the offspring. On the other hand, the mechanisms by which these effects occur are not yet established. In this way, the composition of the milk and the structure of the mammal glands of rats treated with Tityus bahiensis scorpion venom during the breast-feeding will be analyzed in order to verify if the venom is present in the milk and can affect the structure of the gland modifying the quality of the milk or if it can get directly the pups affecting their development. Moreover, it will be verified the level of some neurotransmitters in cerebral structures of these mothers and their pups and of some cytokines in the milk and in the blood of mothers and in the brain and blood of pups since the level of neurotransmitters and cytokines are of utmost importance in the development of the individuals. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NETO, EMIDIO BERALDO; MARIANO, DOUGLAS O. C.; FREITAS, LUCAS A.; DORCE, ANA L. C.; MARTINS, ADRIANA N.; PIMENTA, DANIEL C.; PORTARO, FERNANDA C. V.; CAJADO-CARVALHO, DANIELA; DORCE, VALQUIRIA A. C.; NENCIONI, ANA L. A.. Tb II-I, a Fraction Isolated from Tityus bahiensis Scorpion Venom, Alters Cytokines': Level and Induces Seizures When Intrahippocampally Injected in Rats. TOXINS, v. 10, n. 6, JUN 2018. (16/10196-8)

CORONADO DORCE, VALQUIRIA ABRAO; TEIXEIRA DA ROCHA, MARISA MARIA; CANDIDO, DENISE MARIA; ABRAHAO NENCIONI, ANA LEONOR; VATTI AUADA, ALINE VIVIAN; BARBARO, KATIA CRISTINA; LEBRUN, IVO. Influence of different processing techniques on the toxicity and biochemical characteristics of Tityus serrulatus scorpion venom. Toxicon, v. 156, p. 41-47, DEC 15 2018. (16/10196-8)