Biocompatible nanovectors based on hybrid lamellar materials and composites with polymers for drug release

• Grant number: 16/50317-9
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2017
• End date: July 31, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Agreement: CNRS
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Vera Regina Leopoldo Constantino
• Grantee: Vera Regina Leopoldo Constantino
• Principal researcher abroad: Christiane Taviot-Guého
• Institution abroad: Université Blaise Pascal , France
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated research grant: 11/50318-1 - Development of compounds with pharmacological or medicinal interest and of systems for their transport, detection and recognition in biological media, AP.TEM

Abstract

Nanotechnology advent opens the opportunity to modify biocompatible materials aiming the development of new and effective therapies that meet the demands of the medical field. This project targets to engender nanocarriers of synthetic or natural bioactive species using biocompatible inorganic layered materials (the layered double hydroxides and the cationic clays) and assess the potential for such hybrid systems as therapeutic devices for medical application. Systematic studies will be conducted to the isolation of hybrid systems (bioactive species/layered carrier) to increase the (photo) chemical and/or thermal stabilities of intercalated species and allow their subsequent modified release in the biological environment. In order to modify the process of release of the bioactive species and improve the biocompatibility, it will be prepared composite of hybrid materials with biodegradable polymers. The effect of these materials on the biological environment will be evaluated by "in vivo" assays aiming to collect information about their biocompatibility, toxicity and impact on organ microcirculation. The therapeutic effects of materials with potential anti -inflammatory and antioxidant activity will be assessed against the inflammatory response, integration capacity and tissue repair, through the materials implantation in tissues where lesions were surgically created in regions of interest. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FIGUEIRECLO, MARIANA P.; CUNH, VANESSA R. R.; LEROUX, FABRICE; TAVIOT-GUEHO, CHRISTINE; NAKAMAE, MARTA N.; KANG, YE R.; SOUZA, RODRIGO B.; MARTINS, ANA MARIA C. R. P. F.; JUN KOH, IVAN HONG; CONSTANTINO, VERA R. L.. Iron-Based Layered Double Hydroxide Implants: Potential Drug Delivery Carriers with Tissue Biointegration Promotion and Blood Microcirculation Preservation. ACS OMEGA, v. 3, n. 12, p. 18263-18274, DEC 2018. (14/15900-0, 11/50318-1, 16/13862-9, 16/50317-9)

BIANCONI, LISTER P.; TAVIOT-GUEHO, CHRISTINE; CONSTANTINO, VERA REGINA L.; BIZETO, MARCOS AUGUSTO. Evaluation of the Structural Integrity of Layered Double Hydroxides and Mesoporous Silica During the Preparation of Heterostructures. Journal of the Brazilian Chemical Society, v. N/A, p. 8-pg., 2022-03-08. (19/05467-0, 16/50317-9)

MAGRI, VAGNER R. R.; ROCHA, MICHELE A.; LEROUX, FABRICE; PETRILLI, HELENA M. M.; DE MATOS, CAROLINE S.; PETERSEN, PHILIPPE A. D.; CONSTANTINO, VERA R. L.. Folic acid and sodium folate salts: Thermal behavior and spectroscopic (IR, Raman, and solid-state C-13 NMR) characterization. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 273, p. 13-pg., 2022-02-23. (16/50317-9, 12/06291-4)

CUNHA, VANESSA R. R.; PETERSEN, PHILIPPE A. D.; SOUZA, RODRIGO B.; MARTINS, ANA MARIA C. R. P. F.; LEROUX, FABRICE; TAVIOT-GUEHO, CHRISTINE; PETRILLI, HELENA M.; KOH, IVAN H. J.; CONSTANTINO, VERA R. L.. Phytochemical species intercalated into layered double hydroxides: structural investigation and biocompatibility assays. NEW JOURNAL OF CHEMISTRY, v. 44, n. 24, p. 10011-10021, JUN 28 2020. (16/50317-9, 14/50869-6)

FIGUEIREDO, MARIANA PIRES; CUNHA, VANESSA R. R.; CELLIER, JOEL; TAVIOT-GUEHO, CHRISTINE; CONSTANTINO, VERA R. L.. e(III)-Based Layered Double Hydroxides Carrying Model Naproxenate Anions: Compositional and Structural Aspect. CHEMISTRYSELECT, v. 7, n. 1, JAN 11 2022. (16/13862-9, 16/50317-9, 14/15900-0, 12/12209-9)

FIGUEIREDO, MARIANA PIRES; SUAREZ, EDUARDO DIAZ; PETRILLI, HELENA M.; LEROUX, FABRICE; TAVIOT-GUEHO, CHRISTINE; LEOPOLDO CONSTANTINO, VERA REGINA. Limiting content of trivalent iron to form organic-inorganic single-phase layered double hydroxides hybrids by coprecipitation. APPLIED CLAY SCIENCE, v. 228, p. 10-pg., 2022-07-22. (16/50317-9, 16/13862-9)

CHERIF, NAWAL FODIL; LEOPOLDO CONSTANTINO, VERA REGINA; HAMDAOUI, OUALID; LEROUX, FABRICE; TAVIOT-GUEHO, CHRISTINE. New insights into two ciprofloxacin-intercalated arrangements for layered double hydroxide carrier materials. NEW JOURNAL OF CHEMISTRY, v. 44, n. 24, p. 10076-10086, JUN 28 2020. (16/50317-9)

COUTO, RICARDO ALEXANDRE ALVES; MIGUEL, RODRIGO BERNARDI; VIEIRA, EDUARDO GUIMARAES; BRENDLE, JOCELYNE; LIMOUSY, LIONEL; CONSTANTINO, VERA REGINA LEOPOLDO; FERREIRA, ANA MARIA DA COSTA. Synthetic beidellite clay as nanocarrier for delivery of antitumor oxindolimine-metal complexes. Journal of Inorganic Biochemistry, v. 240, p. 12-pg., 2022-12-28. (11/50318-1, 16/50317-9, 16/16735-8)

FIGUEIREDO, MARIANA PIRES; DUARTE, ALFREDO; VENDRUSCOLO, VICTOR; THIROUARD, RODOLPHE; CONSTANTINO, VERA R. L.; TAVIOT-GUEHO, CHRISTINE. Investigation about iron(III) incorporation into layered double hydroxides: Compositional and structural properties of Mg2FeyAl(1-y)(OH)(6)-Cl and Zn2FeyAl(1-y)(OH)(6)-Cl. Journal of Alloys and Compounds, v. 886, DEC 15 2021. (16/50317-9)

FIGUEIREDO, MARIANA P.; LAYRAC, GERALDINE; HEBRAUD, ANNE; LIMOUSY, LIONEL; BRENDLE, JOCELYNE; SCHLATTER, GUY; CONSTANTINO, VERA R. L.. Design of 3D multi-layered electrospun membranes embedding iron-based layered double hydroxide for drug storage and control of sustained release. EUROPEAN POLYMER JOURNAL, v. 131, MAY 15 2020. (18/22726-7, 16/50317-9)