Advanced search
Start date
Betweenand

Exclusive production of fluoro-unnatural oxindole alkaloids by transgenic Uncaria guianensis via precursor-directed biosynthesis

Grant number: 16/50463-5
Support type:Regular Research Grants
Duration: February 01, 2017 - January 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Adriana Aparecida Lopes
Grantee:Adriana Aparecida Lopes
Home Institution: Universidade de Ribeirão Preto (UNAERP). Campus Ribeirão Preto. Ribeirão Preto , SP, Brazil
Associated research grant:13/07349-9 - Oxindole alkaloids from Uncaria tomentosa: biosynthetic studies and alkaloids analogues obtained by precursor-directed biosynthesis, AP.JP

Abstract

Natural product derivatives or "unnatural products" are known to play a substantial role in drug discovery. Nowadays, there are about 200 pharmaceuticals fluorine containing into various heterocyclic scaffolds and the presence of fluorine atoms within their structures increase the therapeutic efficacy and pharmacological properties. Metabolic engineering strategies to generate "unnatural" monoterpene indole alkaloids have been successful in medicinal plant Catharanthus roses by Dr. Sarah E. O'Connor's Lab, John Innes Centre, and UK. Mutasynthesis strategies mediated by RNA suppression of tryptamine biosynthesis in Catharanthus roses eliminated production of natural monoterpene indole alkaloids and it was possible to obtain desirable unnatural alkaloid production by supplementation with unnatural tryptamine analogues. Uncaria guianensis biosynthesize oxindole alkaloids, which are known to have biological significance, by the same biosynthetically route as found in vinca alkaloids (Catharanthus roseus). Our goal is carry out RNA silencing of tryptophan decarboxylase (TDC) to suppress the biosynthesis of tryptamine in Uncaria guianensis (Rubiaceae) callus culture in order to obtain novel fluoro-unnatural oxindole alkaloids. The combination of genetic manipulation and precursor-directed biosynthesis using unnatural precursors (fluoro-tryptamine) represents an increasingly viable resource to produce unnatural oxindole alkaloids into transgenic callus culture from U. guianensis. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
Study aims at boosting antitumoral activity of compound extracted from an Amazon plant 
Study aims at boosting antitumoral activity of compound extracted from an Amazon plant 
Articles published in other media outlets (22 total):
More itemsLess items
EBC Rádios: Pesquisa aponta potencial da planta unha-de-gato para tratar tumores (26/Nov/2019)
Plantão News (MT): Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (25/Nov/2019)
Confap - Conselho Nacional das Fundações Estaduais de Amparo à Pesquisa: Estudo busca potencializar ação, contra tumores, de composto extraído de planta amazônica (11/Nov/2019)
Saúde Curiosa: "Unha-de-gato": Planta amazônica pode agir contra tumor! (11/Nov/2019)
Hypeness: Planta amazônica que pode agir contra tumor está sendo estudada por cientistas brasileiros (11/Nov/2019)
Jornal da Ciência online: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
TNH1: Cientistas buscam aumentar ação anti-inflamatória da planta amazônica unha-de-gato (07/Nov/2019)
Atemporal: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
Sociedade Científica: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
Comunicação Popular e Comunitária na Amazônia: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
Portal da Enfermagem: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
Jornal Integração: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
NCYT Amazings (Espanha): En busca de potenciar la acción antitumoral de un compuesto extraído de una planta amazónica (05/Nov/2019)
Phys.Org (Reino Unido): Study aims at boosting antitumoral activity of compound extracted from an Amazon plant (01/Nov/2019)
Global Health News Wire (EUA): Study Aims at Boosting Antitumoral Activity of Compound Extracted from an Amazon Plant (01/Nov/2019)
News Medical (Austrália): Increasing anti-tumor activity of compound extracted from an Amazon plant (31/Oct/2019)
Science Codex: Study aims at boosting antitumoral activity of compound extracted from an Amazon plant (31/Oct/2019)
Confederación Farmacéutica Argentina (Argentina): Científicos brasileños buscan potenciar la acción antitumoral de un compuesto extraído de una planta amazónica (31/Oct/2019)
Scienmag Science Magazine (Reino Unido): Study Aims At Boosting Antitumoral Activity Of Compound Extracted From An Amazon Plant (31/Oct/2019)
Brightsurf: Study aims at boosting antitumoral activity of compound extracted from an Amazon plant (31/Oct/2019)
7thSpace: Study aims at boosting antitumoral activity of compound extracted from an Amazon plant (31/Oct/2019)
Biotech News (Austrália): Increasing anti-tumor activity of compound extracted from an Amazon plant (31/Oct/2019)