Developmental aspects of spatial training on the persistence of memory function during normal and pathological aging

• Grant number: 16/50484-2
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2017
• End date: February 28, 2019
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Agreement: Carleton University
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Fernando Augusto de Oliveira Ribeiro
• Grantee: Fernando Augusto de Oliveira Ribeiro
• Principal researcher abroad: Matthew Holahan
• Institution abroad: Carleton University, Canada
• Host Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated research grant: 12/50336-2 - Interaction among hypometabolism, calcium dynamics and neuronal excitability: implications in the degenerative process of Alzheimer's Disease, AP.JP

Abstract

The proposed experiments aim to uncover how, amidst constant metabolic turnover in the brain, memories are stored and become stable, durable and persistent through time. The novelty and significance of this line of work is that little is known concerning the mechanisms underlying memories processed and stored by the juvenile, developing mammalian brain and how they might affect memory processes during normal and pathological aging. The experiments outlined in this proposal will contribute significantly to the field of memory by identifying the crucial structures, proteins and metabolical changes that occur with early experiences to potentially facilitate memory processes throughout the lifespan. This approach is innovative in that it represents a new tool in the study of early life memory processing during development related to early changes in synaptic organization, genetic and metabolic factors. The introduction of more ecologically valid behavioural testing procedures presents a more flexible approach through which more intricate explorations of memory storage can occur. The contributions from this work will help provide the basic knowledge required to address issues of memory enhancements and deficits during the aging and neurodegenerative processes. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVES, VITOR S.; ARCISIO-MIRANDA, MANOEL; CARRETTIERO, DANIEL C.; OLIVEIRA, FERNANDO A.. Transport of Glucose by the Plasma Membrane Affects the Removal and Concentration of Ca2+ at Rest in Neurons - Implications of a Condition Prior to Alzheimer's Disease?. Neuroscience, v. 431, p. 52-63, APR 1 2020. (12/50336-2, 16/17951-6, 16/50484-2)

HOLAHAN, MATTHEW R.; TZAKIS, NIKO; OLIVEIRA, FERNANDO A.. Developmental Aspects of Glucose and Calcium Availability on the Persistence of Memory Function Over the Lifespan. FRONTIERS IN AGING NEUROSCIENCE, v. 11, SEP 11 2019. (12/50336-2, 16/50484-2)

ALVES, VITOR S.; ALVES-SILVA, HELIO S.; ORTS, DIEGO J. B.; RIBEIRO-SILVA, LUISA; ARCISIO-MIRANDA, MANOEL; OLIVEIRA, FERNANDO A.. Calcium Signaling in Neurons and Glial Cells: Role of Cav1 channels. Neuroscience, v. 421, p. 95-111, NOV 21 2019. (12/50336-2, 16/17951-6, 16/50484-2)