Interaction among hypometabolism, calcium dynamics and neuronal excitability: implications in the degenerative process of Alzheimer's Disease

• Grant number: 12/50336-2
• Support Opportunities: Research Grants - Young Investigators Grants
• Duration: March 01, 2013 - February 28, 2018
• Field of knowledge: Biological Sciences - Physiology
• Principal Investigator: Fernando Augusto de Oliveira Ribeiro
• Grantee: Fernando Augusto de Oliveira Ribeiro
• Host Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated grant(s): 16/50484-2 - Developmental aspects of spatial training on the persistence of memory function during normal and pathological aging, AP.R SPRINT

Abstract

Alzheimer's disease (AD) is characterized as a chronic neurodegenerative disorder that affects the individual in adulthood. The brain neurodegenerative process may remain asymptomatic for a long period of time preceding the decline in learning and memory functions, an early sign of pathological changes in AD. Thus, the main challenge is the identification of cellular changes that allow intervention in order to delay, control or prevent the neurodegenerative events before the install to cognitive impairment. Alterations in brain energy metabolism are pointed out as one of the main signs that precede cognitive decline in AD. Several studies show early impairments of the uptake mechanisms and glucose control in the brain of AD patients. GLUT 3, which is the major neuronal glucose transporter, is lowered into the brain of AD patients and modulates a fundamental signal of the pathology, the hyperphosphorylated tau protein. Based on these findings several questions still remain to be clarified in order to elucidate how the decreases in brain energy metabolism could contribute to the development and/or progression of degenerative changes and neuronal modulation of cognitive processes. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BRITO DA SILVA, ANNIELLE MENDES; SILVA-GONCALVES, LAIZ COSTA; OLIVEIRA, FERNANDO AUGUSTO; ARCISIO-MIRANDA, MANOEL. Pro-necrotic Activity of Cationic Mastoparan Peptides in Human Glioblastoma Multiforme Cells Via Membranolytic Action. Molecular Neurobiology, v. 55, n. 7, p. 5490-5504, JUL 2018. (12/02065-0, 16/13368-4, 12/50336-2, 09/53840-0)

FERREIRA, CAROLINE MARCANTONIO; VIEIRA, ANGELICA THOMAZ; RAMIREZ VINOLO, MARCO AURELIO; OLIVEIRA, FERNANDO A.; CURI, RUI; MARTINS, FLAVIANO DOS SANTOS. The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2014. (12/50336-2, 12/10653-9, 12/50410-8)

DIAS DE PAULA, CESAR AUGUSTO; SANTIAGO, FERNANDO ENRIQUE; ALVES DE OLIVEIRA, ADRIELE SILVA; OLIVEIRA, FERNANDO AUGUSTO; ALMEIDA, MARIA CAMILA; CARRETTIERO, DANIEL CARNEIRO. The Co-chaperone BAG2 Mediates Cold-Induced Accumulation of Phosphorylated Tau in SH-SY5Y Cells. Cellular and Molecular Neurobiology, v. 36, n. 4, p. 593-602, MAY 2016. (12/50336-2, 11/06528-1, 09/11446-4)

ALVES, VITOR S.; ALVES-SILVA, HELIO S.; ORTS, DIEGO J. B.; RIBEIRO-SILVA, LUISA; ARCISIO-MIRANDA, MANOEL; OLIVEIRA, FERNANDO A.. Calcium Signaling in Neurons and Glial Cells: Role of Cav1 channels. Neuroscience, v. 421, p. 95-111, NOV 21 2019. (12/50336-2, 16/17951-6, 16/50484-2)

ALVES, VITOR S.; ARCISIO-MIRANDA, MANOEL; CARRETTIERO, DANIEL C.; OLIVEIRA, FERNANDO A.. Transport of Glucose by the Plasma Membrane Affects the Removal and Concentration of Ca2+ at Rest in Neurons - Implications of a Condition Prior to Alzheimer's Disease?. Neuroscience, v. 431, p. 52-63, APR 1 2020. (12/50336-2, 16/17951-6, 16/50484-2)

HOLAHAN, MATTHEW R.; TZAKIS, NIKO; OLIVEIRA, FERNANDO A.. Developmental Aspects of Glucose and Calcium Availability on the Persistence of Memory Function Over the Lifespan. FRONTIERS IN AGING NEUROSCIENCE, v. 11, SEP 11 2019. (12/50336-2, 16/50484-2)

MOREIRA-LOBO, DANIEL C.; CRUZ, JADER S.; SILVA, FLAVIA R.; RIBEIRO, FABIOLA M.; KUSHMERICK, CHRISTOPHER; OLIVEIRA, FERNANDO A.. Thiamine Deficiency Increases Ca2+ Current and Ca(V)1.2 L-type Ca2+ Channel Levels in Cerebellum Granular Neurons. Cellular and Molecular Neurobiology, v. 37, n. 3, p. 453-460, APR 2017. (12/50336-2)