| Grant number: | 16/50296-1 |
| Support Opportunities: | Regular Research Grants |
| Start date: | February 01, 2018 |
| End date: | January 31, 2020 |
| Field of knowledge: | Biological Sciences - Microbiology - Applied Microbiology |
| Agreement: | CNRS |
| Mobility Program: | SPRINT - Projetos de pesquisa - Mobilidade |
| Principal Investigator: | Maria Leonor Sarno de Oliveira |
| Grantee: | Maria Leonor Sarno de Oliveira |
| Principal researcher abroad: | Daniel Ladant |
| Institution abroad: | Institut Pasteur , France |
| Host Institution: | Instituto Butantan. São Paulo , SP, Brazil |
| City of the host institution: | São Paulo |
| Associated research grant: | 16/13134-3 - Recombinant Vaccines against Streptococcus pneumoniae and Bordetella pertussis, AP.R |
Abstract
Streptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia, meningitis and sepsis worldwide. Recent estimates calculate that approximately 500.000 children under 5 die every year from infections caused by S. pneumoniae around the world. The pneumococcal surface protein A (PspA) is a well characterized antigen which confers protection in animal models, representing a good alternative to the present conjugate vaccines. Induction of protective immune response directed at PspA in animal models has been described, however, few low cost adjuvants for the composition of a subunit vaccine, have been proposed to date. In this project, we propose to exploit the adenylate cyclase toxin (CyaA) from Bordetella pertussis as a delivery vector to target PspA to dendritic cells in order to trigger specific and protective responses against the PspA antigen. (AU)
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