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Development of recombinant vaccines against Streptococcus pneumoniae based on the adjuvant activity of the adenylate cyclase toxin from Bordetella pertussis - StrepCyaVac

Grant number: 16/50296-1
Support type:Regular Research Grants
Duration: February 01, 2018 - January 31, 2020
Field of knowledge:Biological Sciences - Microbiology
Cooperation agreement: CNRS
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Maria Leonor Sarno de Oliveira
Grantee:Maria Leonor Sarno de Oliveira
Principal investigator abroad: Daniel Ladant
Institution abroad: Institut Pasteur, France
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:16/13134-3 - Recombinant vaccines against Streptococcus pneumoniae and Bordetella pertussis, AP.R

Abstract

Streptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia, meningitis and sepsis worldwide. Recent estimates calculate that approximately 500.000 children under 5 die every year from infections caused by S. pneumoniae around the world. The pneumococcal surface protein A (PspA) is a well characterized antigen which confers protection in animal models, representing a good alternative to the present conjugate vaccines. Induction of protective immune response directed at PspA in animal models has been described, however, few low cost adjuvants for the composition of a subunit vaccine, have been proposed to date. In this project, we propose to exploit the adenylate cyclase toxin (CyaA) from Bordetella pertussis as a delivery vector to target PspA to dendritic cells in order to trigger specific and protective responses against the PspA antigen. (AU)