Development of recombinant vaccines against Streptococcus pneumoniae based on the adjuvant activity of the adenylate cyclase toxin from Bordetella pertussis - StrepCyaVac

• Grant number: 16/50296-1
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2018
• End date: January 31, 2020
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Agreement: CNRS
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Maria Leonor Sarno de Oliveira
• Grantee: Maria Leonor Sarno de Oliveira
• Principal researcher abroad: Daniel Ladant
• Institution abroad: Institut Pasteur, France
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 16/13134-3 - Recombinant Vaccines against Streptococcus pneumoniae and Bordetella pertussis, AP.R

Abstract

Streptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia, meningitis and sepsis worldwide. Recent estimates calculate that approximately 500.000 children under 5 die every year from infections caused by S. pneumoniae around the world. The pneumococcal surface protein A (PspA) is a well characterized antigen which confers protection in animal models, representing a good alternative to the present conjugate vaccines. Induction of protective immune response directed at PspA in animal models has been described, however, few low cost adjuvants for the composition of a subunit vaccine, have been proposed to date. In this project, we propose to exploit the adenylate cyclase toxin (CyaA) from Bordetella pertussis as a delivery vector to target PspA to dendritic cells in order to trigger specific and protective responses against the PspA antigen. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARNEIRO, GIOVANNA BRITO; CASTRO, JULIA TAVARES; DAVI, MARILYNE; MIYAJI, ELIANE NAMIE; LADANT, DANIEL; OLIVEIRA, MARIA LEONOR SARNO. Immune responses and protection against Streptococcus pneumoniae elicited by recombinant Bordetella pertussis adenylate cyclase (CyaA) carrying fragments of pneumococcal surface protein A, PspA. Vaccine, v. 41, n. 28, p. 13-pg., 2023-06-17. (19/25853-2, 16/13134-3, 21/05671-7, 16/50296-1, 16/17258-9, 17/01701-3)