Adenylate cyclase toxin from Bordetella pertussis as an antigen presentation syste...
| Grant number: | 16/50296-1 |
| Support type: | Regular Research Grants |
| Duration: | February 01, 2018 - January 31, 2020 |
| Field of knowledge: | Biological Sciences - Microbiology |
| Cooperation agreement: | CNRS |
| Mobility Program: | SPRINT - Projetos de pesquisa - Mobilidade |
| Principal Investigator: | Maria Leonor Sarno de Oliveira |
| Grantee: | Maria Leonor Sarno de Oliveira |
| Principal investigator abroad: | Daniel Ladant |
| Institution abroad: | Institut Pasteur, France |
| Home Institution: | Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Associated research grant: | 16/13134-3 - Recombinant vaccines against Streptococcus pneumoniae and Bordetella pertussis, AP.R |
Abstract
Streptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia, meningitis and sepsis worldwide. Recent estimates calculate that approximately 500.000 children under 5 die every year from infections caused by S. pneumoniae around the world. The pneumococcal surface protein A (PspA) is a well characterized antigen which confers protection in animal models, representing a good alternative to the present conjugate vaccines. Induction of protective immune response directed at PspA in animal models has been described, however, few low cost adjuvants for the composition of a subunit vaccine, have been proposed to date. In this project, we propose to exploit the adenylate cyclase toxin (CyaA) from Bordetella pertussis as a delivery vector to target PspA to dendritic cells in order to trigger specific and protective responses against the PspA antigen. (AU)