Multi-user equipament approved in grat 2015/15402-2: cardiorespiratory diagnostic system

• Grant number: 16/26209-1
• Support Opportunities: Multi-user Equipment Program
• Start date: April 01, 2017
• End date: March 31, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Otávio Rizzi Coelho-Filho
• Grantee: Otávio Rizzi Coelho-Filho
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 15/15402-2 - Characterization of interstitial fibrosis and cardiomyocyte hypertrophy by cardiac MRI: implication on early remodeling and on the transition to heart failure, AP.JP
• EMU web page: https://www.fcm.unicamp.br/fcm/centro-de-pesquisa-clinica-cpc/equipamento-multiusuario-emu/ecocardiograma-modelo-vivid-s6
• Type of equipment: Caracterização e Análises de Amostras - Biomédica - Corporal
• Manufacturer: MedGraphics
• Model: Ultima Cardio2 com bicicleta ergométrica

Abstract

hemodynamic stimuli across physiologic (e.g., exercise) and pathologic states (e.g., hypertension, aortic stenosis). The extent ofmyocardial hypertrophy is determined by a combination of cardiomyocyte size and extracellular volume (ECV) expansion/interstitialfibrosis: while physiologic (exercise-induced) hypertrophy reflects mostly reversible cardiomyocyte hypertrophy, pathologic hypertrophy(e.g., in heart failure) is a combination of both interstitial fibrosis (potentially irreversible) and cardiomyocyte hypertro-phy (reversible).Current methods to delineate the potential for LV reverse remodeling (e.g., natriuretic peptides and echocardiographic or clinicalmarkers) detect primarily advanced disease, missing a critical opportunity to intervene and follow patients at an early disease phasewhere myocardial pathology may be reversible. Therefore, establishing novel, quantitative metrics of myocardial tissue phenotype thatdefine a transition from hypertrophy to fibrosis, and then to irreversible LV remodeling/dysfunction may facilitate targeting therapies ata modifiable stage of disease in HF. Our group has recently extended cardiac T1 mapping MRI techniques to quantify the intracellularlifetime of water (Äic) serially as an index of cardiomyocyte diameter, validating this technique histologically in mouse models ofpressure overload. The central hypothesis of this application is that these novel MRI metrics will define the role of fibrosis andcardiomyocyte size in the development of LV remodeling/HF and will be associated with prognostically important indices in HFdevelopment. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEZEL, THEO; SILVA, LUIS MIGUEL; BAU, ADRIANA APARECIA; TEIXIERA, ADHERBAL; JEROSCH-HEROLD, MICHAEL; COELHO-FILHO, OTAVIO R.. What Is the Clinical Impact of Stress CMR After the ISCHEMIA Trial?. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 8, JUN 4 2021. (16/26209-1, 15/15402-2, 17/03708-5)

JEROSCH-HEROLD, MICHAEL; RICKERS, CARSTEN; PETERSEN, STEFFEN E. E.; COELHO-FILHO, OTAVIO R.. Myocardial Tissue Characterization in Cardiac Magnetic Resonance Studies of Patients Recovering From COVID-19: A Meta-Analysis. JOURNAL OF THE AMERICAN HEART ASSOCIATION, v. 12, n. 6, p. 22-pg., 2023-03-21. (17/03708-5, 16/26209-1, 15/15402-2)

TAKAZAKI, KAREN A. G.; QUINAGLIA, THIAGO; VENANCIO, THIAGO D.; MARTINEZ, ALBERTO R. M.; SHAH, RAVI V.; NEILAN, TOMAS G.; JEROSCH-HEROLD, MICHAEL; COELHO-FILHO, OTAVIO R.; FRANCA, JR., MARCONDES C.. Pre-clinical left ventricular myocardial remodeling in patients with Friedreich's ataxia: A cardiac MRI study. PLoS One, v. 16, n. 3, MAR 26 2021. (15/15402-2, 13/01766-7, 16/26209-1, 17/03708-5)

DE SOUZA, THIAGO FERREIRA; SILVA, THIAGO QUINAGLIA; ANTUNES-CORREA, LIGIA; DROBNI, ZSOFIA D.; COSTA, FELIPE OSORIO; DERTKIGIL, SERGIO SAN JUAN; NADRUZ, WILSON; BRENELLI, FACRICIO; SPOSITO, ANDREI C.; MATOS-SOUZA JR, JOSE ROBERTO; et al. Cardiac magnetic resonance assessment of right ventricular remodeling after anthracycline therapy. SCIENTIFIC REPORTS, v. 11, n. 1, AUG 24 2021. (16/26209-1, 15/15402-2, 17/03708-5)

GEMME, CRISTIANE NARDI; SILVA, THIAGO QUINAGLIA A. C.; MARTINS, LUIZ C.; DA SILVA, LUIS MIGUEL; PAIM, LAYDE ROSANE; SPOSITO, ANDREI; NADRUZ, WILSON; FERNANDES, FABIO; DERTKIGIL, SERGIO SAN JUAN; WANDERLEY, JAMIRO DA SILVA; et al. Diffuse Myocardial Fibrosis and Cardiomyocyte Diameter Are Associated With Heart Failure Symptoms in Chagas Cardiomyopathy. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 9, p. 12-pg., 2022-06-17. (15/15402-2, 16/26209-1, 17/03708-5)

TOLEDO, CAMILA CRISTIANE; VELLOSA SCHWARTZMANN, PEDRO; MIGUEL SILVA, LUIS; DA SILVA FERREIRA, GABRIEL; BIANCHINI CARDOSO, FERNANDO; CITELLI RIBEIRO, VINICIUS; PAIM, LAYDE ROSANE; ANTUNES-CORREA, LIGIA M.; CARVALHO SPOSITO, ANDREI; MATOS SOUZA, JOSE ROBERTO; et al. Serum potassium levels provide prognostic information in symptomatic heart failure beyond traditional clinical variables. ESC HEART FAILURE, MAR 2021. (17/03708-5, 15/15402-2, 16/26209-1)