Multiscale osteoconductive surface coating for titanium based implants

• Grant number: 16/08359-6
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: July 01, 2017
• End date: August 31, 2018
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Diego Pedreira de Oliveira
• Grantee: Diego Pedreira de Oliveira
• Company: Extremus Smart Surface - Tratamentos de Superfície Ltda
• City: São Carlos
• Associated researchers: Luis Felipe Sverzut Baroni
• Associated research grant(s): 19/10484-1 - Development of multiscale surface treatment for titanium based implants, AP.PIPE
• Associated scholarship(s): 17/20746-8 - Multiscale osteoconductive surface coating for Ti-based implants, BP.PIPE

Abstract

The current tendency of research and development of biomedical materials is focused on the achievement of certain characteristics that promotes biological activities in such a manner to induce or accelerate answers that will lead to a shorter postoperative period. In intraosseous implants, researches are seeking surfaces that will exert adequate biological answers to osteoblasts in order to enhance osseointegration. For industrial coating applications uses processing to obtain a macro roughness exposing the physiologic environment to a nontoxic chemical composition. The objective is to promote the primary mechanical stability (anchorage) avoiding the relative movement between the bone and the implant that can cause a local tissue inflammation. Recent researches focus on surface modification that will control its properties from macro to nanometric levels. Scientists realized that develop multiscale topography have a potential to accelerate biological events that precede the reconstruction of tissues damaged by a trauma, disease or congenital factors. To develop, characterize physic-chemically and biologically the implant surfaces containing macro, micro and nanotopography in samples of titanium based materials. It is divided in the following procedures: sample preparation, physical-chemical, biological surface characterization and bioactivity tests. Find a surface combining chemical bioactivity and osteoconductivity, the first one measured by immersion in Simulated Body Fluid (SBF) and the latter with osteoblastic responses. The formation of macro-roughness with microporosity and a nanotopographyc layer over the material surface intend to satisfy the requirements for chemical bioactivity and osteoconductivity, finding favorable biological answers during in vitro testing. There is an immediate impact in the technology for orthopedic and dental implant industry. Moreover, a reduction on the hospitalization period, which can lead to a cost reduction for medical insurances and government health system, is expected. (AU)