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An aminocatalyzed stereoselective strategy for the formal alpha-propargylation of ketones

Abstract

A two-step reaction sequence is described for the asymmetric formal alpha-propargylation of ketones. This approach takes advantage of an aminocatalyzed conjugate addition of ketones to alkylidene isoxazol-5-ones, followed by a controlled nitrosative degradation event. The target compounds can be accessed in broad scope, in moderate to good yields, perfect diastereocontrol and good to excellent enantioselectivities. (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)