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Design, synthesis and applications of new organocatalysts in stereoselective Henry (nitroaldol) reactions

Grant number: 15/12518-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2015
Effective date (End): July 31, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Alessandro Rodrigues
Grantee:Bruna Papa Spadafora
Home Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

This proposal focuses on the development of new organic catalysts and their applications in Henry reactions (nitroaldol) enantioselective. The rational design of new chiral catalysts has been a challenge to chemistry. In the first stage of this proposal molecular modeling applied to stereoselective catalysis presented crucial role in designing a new organocatalisador. At this stage the project will be continued in order to design more effective organocatalysts for enantioselective Henry reaction. Asymmetric organocatalysis has significant potential for the synthesis of synthetic intermediates of high added value. We intend to collaborate with this area of research in expansion, investigating the synthesis and application of novel catalysts. The aim is to develop new chiral organocatalysts based functional group thiourea, applying them in Henry Reaction (nitroaldol) derivative of benzaldehyde and nitromethane. During the development of the study, we intend to collaborate training Bruna Lacerda Papa in organic synthesis. This proposal focuses on the development of new organic catalysts and their applications in Henry reactions (nitroaldol) enantioselective. The rational design of new chiral catalysts has been a challenge to chemistry. In the first stage of this proposal molecular modeling applied to stereoselective catalysis presented crucial role in designing a new organocatalisador. At this stage the project will be continued in order to design more effective organocatalysts for enantioselective Henry reaction. Asymmetric organocatalysis has significant potential for the synthesis of synthetic intermediates of high added value. We intend to collaborate with this area of research in expansion, investigating the synthesis and application of novel catalysts. The aim is to develop new chiral organocatalysts based functional group thiourea, applying them in Henry Reaction (nitroaldol) derivative of benzaldehyde and nitromethane. During the development of the study, we intend to collaborate training Bruna Lacerda Papa in organic synthesis (AU)

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