Assessment of inflammatory response of postoperative patients with small aortic annulus after implantation of perceval valve prosthesis and its impact on short and medium term survival

• Grant number: 16/18760-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2017
• End date: January 31, 2020
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Amanda Guerra de Moraes Rego Souza
• Grantee: Amanda Guerra de Moraes Rego Souza
• Host Institution: Instituto Dante Pazzanese de Cardiologia (IDPC). Fundação Adib Jatene (FAJ). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Luiz Carlos Bento de Souza ; Magaly Arrais dos Santos

Abstract

SIRS (Systemic Inflammatory Response Syndrome) is related to an increase in the number of circulating endothelial microparticles as markers of endothelial impairment in patients with aortic stenosis and/or patients in postoperative recovery after having undergone an aortic valve replacement surgery. An implanted Perceval S prosthetic valve reduces aortic clamping time and total surgical time, offers better hemodynamic performance - with a lower residual aortic transvalvular gradient - and thus contributes to reduce inflammatory response, due to lower levels of circulating micro-particles in the postoperative period when compared to the use of conventional bioprosthetic valves. The purpose of this study will be to assess the impact of inflammatory responses on short- and medium term survival rates, and its relation to the levels of endothelial microparticles among patients with small aortic annulus having undergone implantation of a conventional biological prosthesis or a Perceval Sutureless prosthesis. A prospective, randomized study will be conducted involving 24 patients who will undergo isolated aortic valve replacement surgery. The patients will be divided into two groups: those with Perceval valves (P Group) and those with conventional bioprosthetic valves ("C Group"). The following will be evaluated: the release profile of endothelial microparticles, and the plasma concentration of inflammatory markers; Interleukins-6 and -8; reactive C protein; the levels of procalcitonin (preoperative, and 24-hour and 3-month postoperative), and their relation to an inflammatory response. A transthoracic echocardiogram will be performed during the postoperative (30-day, 6-month and 12-month) follow-up period. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JENNY LOURDES RIVAS DE OLIVEIRA; MAGALY ARRAIS DOS SANTOS; ARI TIMERMAN. Endothelial Microparticles: Markers of Inflammatory Response After Sutureless Valve Implantation. Revista Brasileira de Cirurgia Cardiovascular, v. 39, n. 1, 2023-10-30. (16/18760-0)