Synthesis of Pioglitazone, Rosiglitazone and Lobeglitazone in continuous flow in capillary microreactors

• Grant number: 17/12830-9
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2017
• End date: July 31, 2020
• Field of knowledge: Engineering - Chemical Engineering - Chemical Technology
• Principal Investigator: Mauri Sergio Alves Palma
• Grantee: Mauri Sergio Alves Palma
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated researchers: Sylvio Jorge Hares Junior

Abstract

Microreactors offer excellent heat and mass transfer, high surface/volume ratio with laminar flow and without axial dispersion. Microreactors have been used in the continuous-flow synthesis of pharmaceuticals, creating chemical libraries of compounds with pharmacological potential, continuous synthesis in multiple steps, particularly for rapid reactions that involve much heat, chemical process intensification and with chemical reactions where dangerous, toxic or explosive chemicals are present. Some advantages of drug synthesis in microreactors are the drastic reduction of reaction times, due to the elimination of inefficient mixing effects, increased yield and selectivity of the reactions and reduction of waste generation. The Chemical-Pharmaceutical Industry is the largest beneficiary of this new technology, because the microreactors can generate a number of compounds with pharmacological potential, several orders of magnitude greater than in traditional batch process, can lessen in years the time for commercial production of a new drug and can be extremely small and compact industrial units. This work aims at using a system of microreactors to produce the APIs Pioglitazone (Actos®), Rosiglitazone (Avandia®) and Lobeglitazona (Duvie®) for the first time in continuous flow process, determining the kinetics of those reactions, and the best operating conditions for each synthesis. This project will be developed in collaboration with Profs. Till Opatz (Johannes Gutenberg-University Mainz, Germany) who idealized the synthetic routes of the APIs, and Prof. Hans-Joerg Bart (Technical University of Kaiserslautern, Germany) who developed the purification processes of the intermediate products by liquid-liquid extraction in micro devices. (AU)

Scientific publications

(5)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

OLIVIERI, GUSTAVO, V; MEIRA, PAULA A.; DE MATTOS, THAYANA T.; OKUDA, HENRIQUE M.; DE QUADROS JR, JACYR V.; PALMA, MAURI S. A.; GIUDICI, REINALDO. Microreactor x millireactor: Experimental performance in the epoxidation of soybean oil. CHEMICAL ENGINEERING AND PROCESSING, v. 193, p. 9-pg., 2023-10-09. (15/50684-9, 21/13315-6, 17/12830-9, 22/01982-0)

SILVA, RENAN RODRIGUES DE OLIVEIRA; CALVO, PAULO VICTOR CUESTA; MERFELS, CHRISTIAN ADRIAN; LIMA, MIKAEL VITOR RODRIGUES; SANTANA, HARRSON S.; CONVERTI, ATTILIO; PALMA, MAURI SERGIO ALVES. Synthesis of Lobeglitazone intermediates seeking for continuous drug production in flow capillary microreactor. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 116, p. 11-pg., 2022-10-25. (18/01478-5, 17/12830-9, 18/26717-2)

CUESTA CALVO, PAULO VICTOR; BATISTA, PATRICK RODRIGUES; DE OLIVEIRA SILVA, RENAN RODRIGUES; CONVERTI, ATTILIO; AL ARNI, SALEH; SOLISIO, CARLO; DUCATI, LUCAS C.; ALVES PALMA, MAURI SERGIO. Flow Synthesis of 2-[Methyl(pyridin-2-yl)amino]ethanol: An Experimental and Computational Study. CHEMICAL ENGINEERING & TECHNOLOGY, v. 44, n. 2, DEC 2020. (18/07308-4, 17/12830-9, 18/26717-2, 20/10246-0, 18/01478-5, 17/17750-3)

SIGUEMOTO, ERICA S.; LEITE RECHE, LEANDRO; GUT, JORGE A. W.; PALMA, MAURI S. A.. Residence Time Distribution of a Capillary Microreactor Used for Pharmaceutical Synthesis. CHEMICAL ENGINEERING & TECHNOLOGY, v. 43, n. 3, JAN 2020. (13/07914-8, 17/12830-9, 14/07757-2)

SILVA, RENAN RODRIGUES DE OLIVEIRA; MEIRA, PAULA ALMEIDA; MERFELS, CHRISTIAN ADRIAN; PALMA, MAURI SERGIO ALVES. Improvements to the Pioglitazone synthetic route using microreactor technology and aspects of green chemistry. CHEMICAL ENGINEERING RESEARCH & DESIGN, v. 218, p. 10-pg., 2025-06-01. (18/01478-5, 17/12830-9, 22/12414-3)

Filed patent(s) as a result of this research project