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Evaluation of the function of the masticatory muscles and physiologic sleep variables after therapies of electro-mechanical bioestimulation and use of intraoral device in patients with Down syndrome: electromyography, polysomnography and salivary parameters

Grant number: 17/06835-8
Support type:Regular Research Grants
Duration: September 01, 2017 - February 29, 2020
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Mônica Fernandes Gomes
Grantee:Mônica Fernandes Gomes
Home Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil
Assoc. researchers:Cristiane Yumi Koga Ito ; João Carlos da Rocha ; José Benedito Oliveira Amorim ; Lilian Chrystiane Giannasi Marson ; Luís Vicente Franco de Oliveira
Associated scholarship(s):17/21499-4 - Evaluation of the function of the masticatory muscles and physiologic sleep variables after therapies of electro-mechanical bioestimulation and use of intraoral device in patients with Down syndrome: electromyography, polysomnography and salivary parameters, BP.TT

Abstract

Down Syndrome (DS) is the most common genetic disorder in the population. Muscle hypotonicity is one of the main characteristic of this syndrome, resulting in an impairment of speech, swallowing and chewing in this population. In addition, pharyngeal hypotonicity will favor total or partial upper airway obstruction during sleep, resulting in snoring and obstructive sleep apnea (OSA), which is an evolutionary disorder, associated to high risk for mortality and morbidity in DS individuals.The aim of this research project will be perform a randomized controlled clinical trial, which will evaluate the masticatory function (masseter, temporals and supra hyoid muscles) through electromyography (EMG), the physiological sleep variables through polysomnography (PSG) and the salivary parameters in individuals with DS, prior and post two months of application of neuromuscular electrical stimulation surface (NMEEs), Hybebola chewing apparatus (HB) and oral alliance (OA). The research subjects will be randomly divided in three groups ( DS-NMEEs, DS-HB,DS-OA). Primary outcome would be the improvement and/or recovery of muscular function in DS individuals, once the generalized hypotonicity is an inherent feature of DS population, as well as the improvement in the physiological sleep variables which are influenced by hypotonic condition of the pharynx. Second outcome would be the possibility of measuring the compliance / adherence to each proposed therapy and also measure how each therapy changed the the muscular function, the physiological sleep variables and salivary parameters of all r subjects enrolled in this project. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES, MONICA FERNANDES; GIANNASI, LILIAN CHRYSTIANE; FILLIETAZ-BACIGALUPO, ELAINE; DE MANCILHA, GABRIELA PINTO; DE CARVALHO SILVA, GABRIELA RAINE; SOVIERO, LAURA DIAS; DA SILVA, GABRIELLA YASMIN SANTOS; NAZARIO, LETICIA DE MIGUEL; DUTRA, MARIGNES THEOTONIO DOS SANTOS; SILVESTRE, PEDRO RIBEIRO; DE OLIVEIRA, LUIS VICENTE FRANCO; NACIF, SERGIO ROBERTO; DE OLIVEIRA, EZEQUIEL FERNANDES; SERAFIM, IRENE MOREIRA; PEREIRA, BRUNA DICIERI; GRECA, AMANDA REIS; GOULART, MARIA DAS GRACAS VILELA; RODE, SIGMAR DE MELLO; TANAKA, MARCIA HIROMI; KOGA-ITO, CRISTIANE YUMI; AMORIM, JOSE BENEDITO DE OLIVEIRA; SALGADO, MIGUEL ANGEL CASTILLO. Evaluation of the masticatory biomechanical function in Down syndrome and its Influence on sleep disorders, body adiposity and salivary parameters. Journal of Oral Rehabilitation, v. 47, n. 8 JUN 2020. Web of Science Citations: 0.
GIANNASI, LILIAN CHRYSTIANE; DUTRA, MARIGNES T. S.; TENGUAN, VERA L. S.; MANCILHA, GABRIELA P.; SILVA, GABRIELA R. C.; FILLIETAZ-BACIGALUPO, ELAINE; DA SILVA, DANIEL B.; POLITTI, FABIANO; NACIF, SERGIO R.; DE OLIVEIRA, EZEQUIEL F.; DA ROCHA, JOAO C.; ROCHA, CAROLINA T.; ROMERO, MATEUS M.; DE OLIVEIRA, CLAUDIA S.; DE OLIVEIRA, LUIS V. F.; RODE, SIGMAR DE MELLO; KOGA-ITO, CRISTIANE YUMI; AMORIM, JOSE B. O.; SALGADO, MIGUEL A. C.; GOMES, MONICA F. Evaluation of the masticatory muscle function, physiological sleep variables, and salivary parameters after electromechanical therapeutic approaches in adult patients with Down syndrome: a randomized controlled clinical trial. Trials, v. 20, APR 11 2019. Web of Science Citations: 0.
GOMES, MONICA FERNANDES; BERNARDO SICHI, LUIGI GIOVANNI; GIANNASI, LILIAN CHRYSTIANE; OLIVEIRA AMORIM, JOSE BENEDITO; DA ROCHA, JOAO CARLOS; KOGA-ITO, CRISTIANE YUMI; CASTILLO SALGADO, MIGUEL ANGEL. Phenotypic Features and Salivary Parameters in Patients with Ectodermal Dysplasia: Report of Three Cases. CASE REPORTS IN DENTISTRY, 2018. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.