Development of biocompatible and bioactive meshes composed of nano- and microfiber for dental and medical applications

• Grant number: 16/21864-1
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: November 01, 2017
• End date: July 31, 2018
• Field of knowledge: Engineering - Biomedical Engineering
• Principal Investigator: Guinea Brasil Camargo Cardoso
• Grantee: Guinea Brasil Camargo Cardoso
• Company: Neomeshes Biomateriais Ltda. - ME
• City: Brotas
• Pesquisadores principais: Danilo Siqueira Pino ; Francisco José de Nadai Dias ; Stella Aparecida de Andrade Pinto
• Associated researchers: Cecilia Amelia de Carvalho Zavaglia ; Marcelo Rodrigues da Cunha ; Mariana Motisuke
• Associated scholarship(s): 17/23743-0 - Development of biocompatible and bioactive meshes composed of nano- and microfiber for dental and medical applications, BP.PIPE

Abstract

Tissue engineering is a relatively new concept in the treatment of diseases and injuries. This area encompasses the use of molecular and cell biology technology, combining the advantages of materials and processing science in order to produce tissue regeneration in situations there change has determined that tissue does not have the regenerative capacity over time. The essence of tissue engineering is that all cells are viable and initiation capability support and regeneration are linked directly by growth factors or genes so that they produce a new variety of fabric required. This can be achieved with the aid of a scaffold or matrix geometrically guided form or an architecture of a new tissue and can thus customize a basic place over a wound on a patient isolated or greater industrial scale, a living bioreactor, where resulting fabric is constructed reimplanted on the patient. This project shows the development of mesh polycaprolactone (PCL) / beta-tricalcium phosphate (²-TCP), PCL / resveratrol / collagen, PCL / curcumin / collagen, PDLLA / resveratrol / collagen. The development has the support of Professor. Dr. Cecilia Amelia Carvalho Zavaglia, deputy coordinator of BIOFABRIS (National Institute of Biomanufacturing) which will host the development of research development and innovation project. In addition to the infrastructure BIOFABRIS, the project will consist of the company's resources to be installed. (AU)