Myeloperoxidase is not a good biomarker for preeclâmpsia prediction

• Grant number: 17/14546-6
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Start date: November 01, 2017
• End date: April 30, 2018
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Valeria Cristina Sandrim
• Grantee: Valeria Cristina Sandrim
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Myeloperoxidase is a proinflammatory enzyme found to be increased in patients with established preeclampsia but never investigated before the disease onset. Here we examined myeloperoxidase concentration and activity in plasma and urine samples from pregnant women who remained normotensive throughout pregnancy and those who developed preeclampsia in order to assess its potential to predict this disorder. Our sample consisted of 30 cases who developed preeclampsia (14 severe and 16 mild) and 57 controls who remained healthy throughout pregnancy, derived from the Brazilian Ribeirão Preto and São Luís prenatal cohort (BRISA). Myeloperoxidase concentration were assessed using a commercial ELISA kit and enzymatic activity through tetramethylbenzidine oxidation. No statistical differences were found in myeloperoxidase levels nor activity between plasma or urine samples from controls, severe and mild cases. Myeloperoxidase did not seem to have a potential application for preeclampsia prediction. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROCHA-PENHA, L.; BETTIOL, H.; BARBIERI, M. A.; CARDOSO, V. C.; CAVALLI, R. C.; SANDRIM, V. C.. Myeloperoxidase is not a good biomarker for preeclampsia prediction (vol 7, 10257, 2017). SCIENTIFIC REPORTS, v. 8, p. 1-pg., 2018-03-08. (15/20461-8, 08/53593-0, 17/14546-6)