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Identification of First-trimester Prognostic Urinary Biomarkers for Preeclampsia and Other Pregnancy Complications

Abstract

INTRODUCTION: Preeclampsia, gestational diabetes mellitus, fetal growth restriction and preterm delivery are common pregnancy complications and principal causes of perinatal morbidity and mortality. The research and development of reliable biochemical markers for prediction and diagnosis of pregnancy complications may have a great impact on maternal health and several have been suggested. Although there are many data on biochemical markers in the blood and pregnancies outcomes, few studies have evaluated their values in the urine of pregnant women. OBJECTIVES: The overall objective of our study is to evaluate novel biomarkers, predictive of disease, that are present and measurable in whole urine of pregnant women. We aim at determining the predictive accuracy of novel urinary biomarkers of first trimester for pregnancy complications in women. Our specific objectives are to: a) Investigate the predicting sensitivity and specificity of pregnancy complications with selected urinary biomarkers, b) Assess potential synergy of a combined biomarkers approach to predict pregnancy outcomes.METHODS: This will be a prospective longitudinal observational of a cohort of pregnant women from Vale do Paraiba, Sao Jose dos Campos enrolled for prenatal care at Santa Casa de Sao Jose dos Campos. The cohort will be screened for possible urinary biomarkers at the end of the first trimester of pregnancy and will be followed up for pregnancy complications. Targeted biomarkers to be studied are: angiotensinogen, melatonin, heat shock proteins HSP 70 &90, and feto-placental factors including human chorionic gonadotropin (hCG), estriol, alpha fetoprotein (AFP), and pregnancy-associated plasma protein-A (PAPP-A).EXPECTED RESULTS AND SIGNIFICANCE OF THE PROJECT:We hope the results of this proposed project will provide us with advancement in early diagnosis of pregnancy-associated diseases. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA MEDEIROS, THAMILA KAMILA; DOBRE, MIRELA; BAPTISTA DA SILVA, DANIELA MONTEIRO; BRATEANU, ANDREI; BALTATU, OVIDIU CONSTANTIN; CAMPOS, LUCIANA APARECIDA. Intrapartum Fetal Heart Rate: A Possible Predictor of Neonatal Acidemia and APGAR Score. FRONTIERS IN PHYSIOLOGY, v. 9, OCT 22 2018. Web of Science Citations: 0.

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