NANOSTRUCTURED SYSTEMS WITH POTENTIAL APPLICATION IN TREATMENT OF NEGLECTED DISEASES

• Grant number: 17/08332-3
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2017
• End date: November 30, 2019
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Nádia Araci Bou-Chacra
• Grantee: Nádia Araci Bou-Chacra
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated researchers: Chung Man Chin ; Paulo Cesar Cotrim ; Raimar Lobenberg
• Associated research grant(s): 18/22521-6 - Lymphatic targeted nanotechnology-based drug delivery system for the treatment of leishmaniasis, AP.R SPRINT

Abstract

Neglected tropical diseases (NTDs) are infectious diseases that affect poor populations living mainly in the tropical and subtropical regions. In this environment, lack of sanitation and lack of access to the health system facilitate the transmission of diseases and the proliferation of vectors. It is estimated that these diseases can reach more than one billion people globally and account for more than one million deaths each year in 149 countries with annual costs of billions of dollars. Thus, the search for treatments with greater therapeutic efficacy, greater safety and with shorter duration of treatment for the patients affected by neglected diseases is urgent. In this sense, nanostructured systems have demonstrated a high potential of application in the development of innovative medicines. Among the methods, we highlight those by high energy, high-pressure homogenization and high-energy milling, and low energy, as in the case of the D-phase emulsification (DFE). These methods, among other advantages, allow the obtaining of nanostructured lipid carriers, nanoemulsions and nanocrystals, on an industrial scale. The objective of this work is the development and the physical-chemical and biological characterization of nanostructured systems with potential application in the treatment of tuberculosis and leishmaniasis. In addition, the study will allow broadening the knowledge regarding the process of obtaining nanoemulsions via DFE, still little explored among those of low energy. As a model, the drugs rifampicin and burpavaquone, as well as the drug candidate hydroxymethylnitrofurazone (NFOH) will be employed. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE SOUZA, ALINE; YUKUYAMA, MEGUMI NISHITANI; BARBOSA, EDUARDO JOSE; MONTEIRO, LIS MARIE; BREITHAUPT FALOPPA, ANA CRISTINA; CALIXTO, LEANDRO AUGUSTO; DE BARROS ARAUJO, GABRIEL LIMA; FOTAKI, NIKOLETTA; LOBENBERG, RAIMAR; BOU-CHACRA, NADIA ARACI. A new medium-throughput screening design approach for the development of hydroxymethylnitrofurazone (NFOH) nanostructured lipid carrier for treating leishmaniasis. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 193, SEP 2020. (17/08332-3)

DE SOUZA, ALINE; LIMA DE ALMEIDA, MARIA KARILLY; BARBOSA, JOAO ANTONIO; YUKUYAMA, MEGUMI NISHITANI; CORREIA, CRISTIANO JESUS; BREITHAUPT-FALOPPA, ANA CRISTINA; BOU-CHACRA, NADIA ARACI; CALIXTO, LEANDRO AUGUSTO. Development of an HPLC Method for Identification and Quantification of Anti-leishmaniasis Drug Candidate NFOH After Oral Administration of NLC-NFOH in Rats. CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY, v. N/A, p. 7-pg., 2022-11-28. (17/08332-3)

BAZAN HENOSTROZA, MIRLA ANALI; CURO MELO, KATHERINE JASMINE; YUKUYAMA, MEGUMI NISHITANI; LOBENBERG, RAIMAR; BOU-CHACRA, NADIA ARACI. Cationic rifampicin nanoemulsion for the treatment of ocular tuberculosis. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 597, JUL 20 2020. (17/08332-3)

DE SOUZA, ALINE; SCARIM, CAUE BENITO; COTRIM, PAULO CESAR; BARBOSA JUNIOR, FERNANDO; ROCHA, BRUNO ALVES; CALIXTO, LEANDRO AUGUSTO; CORREIA, CRISTIANO JESUS; ARAUJO, GABRIEL LIMA DE BARROS; LOBENBERG, RAIMAR; BOU-CHACRA, NADIA ARACI; et al. Hydroxymethylnitrofurazone lymphatic uptake with nanostructured lipid carrier after oral administration in rats. Nanomedicine, v. 19, n. 4, p. 9-pg., 2024-01-25. (17/08332-3)

YUKUYAMA, MEGUMI NISHITANI; ZUO, JIEYU; PARK, CHULHUN; YOUSEF, MALAZ; BAZAN HENOSTROZA, MIRLA ANALI; BARROS DE ARAUJO, GABRIEL LIMA; BOU-CHACRA, NADIA ARACI; LOBENBERG, RAIMAR. Biphasic dissolution combined with modified cylinder method-A new promising method for dissolution test in drug-loaded nanoemulsions. International Journal of Pharmaceutics, v. 632, p. 9-pg., 2023-01-06. (18/22713-2, 20/15981-0, 19/04998-2, 17/08332-3)

YUKUYAMA, MEGUMI NISHITANI; MYIAKE KATO, EDNA TOMIKO; BARROS DE ARAUJO, GABRIEL LIMA; LOBENBERG, RAIMAR; MONTEIRO, LIS MARIE; LOURENCO, FELIPE REBELLO; BOU-CHACRA, NADIA ARACI. Olive oil nanoemulsion preparation using high-pressure homogenization and D-phase emulsification - A design space approach. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 49, p. 622-631, FEB 2019. (17/08332-3)

DE SOUZA, ALINE; SOUZA MARINS, DEBORA SOARES; MATHIAS, SAMIR LEITE; MONTEIRO, LIS MARIE; YUKUYAMA, MEGUMI NISHITANI; SCARIM, CAUE BENITO; LOBENBERG, RAIMAR; BOU-CHACRA, NADIA ARACI. Promising nanotherapy in treating leishmaniasis. International Journal of Pharmaceutics, v. 547, n. 1-2, p. 421-431, AUG 25 2018. (17/08332-3)

Filed patent(s) as a result of this research project