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Effect of strength training and vascular occlusion on vascular reactivity of the abdominal aorta in wistar rats

Grant number: 17/13348-6
Support type:Regular Research Grants
Duration: February 01, 2018 - April 30, 2020
Field of knowledge:Biological Sciences - Physiology - Physiology of Effort
Principal Investigator:Enrico Fuini Puggina
Grantee:Enrico Fuini Puggina
Home Institution: Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Camila de Moraes

Abstract

Exercise training is the major lifestyle change that can significantly reducecardiovascular events and that strength training has been one of the main types ofexercises used today. When done with high intensity (greater than 70% of 1MVC)produces morphological and functional adaptations muscle as a consequence of metabolicstress. However, it is known that a high load is often associated with orthopediccomplications and furthermore, the high intensity training (greater than 80% of 1RM) hasbeen associated with deleterious effects on vascular adaptations. Alternatively, studieshave shown that strength training and vascular occlusion (TFO) made with low intensity(20-50% 1MVC) causes beneficial adaptations similar to strength training with greaterintensity than 70% 1MVC. However, the vast majority of studies investigated the effectsof strength training with related vascular occlusion muscle adaptations and at the moment,no studies evaluating the effects of strength training and vascular occlusion in vascularfunction. For this, we used mice at 8 weeks of age, submitted a strength training protocolwith vascular occlusion for four weeks. Concentration-response curves to acetylcholine(ACh), sodium nitroprusside (NPS) and phenylephrine (PHE) will be performed in theabdominal aortic. In addition, an analysis of the expression of superoxide dismutaseproteins, tumor necrosis factor alpha, thiobarbituric acid reactive substances in the aortamay indicate the mechanisms involved in the responses. The investigation of theprocesses involved in the process could be elucidated in populations at risk, as examplein individuals with cardiovascular disease, the TFO would also be a safe and effectivetraining method, since this training method has beem increasingly popularized and usedin different situations. (AU)