Effects of isoflavones derived from Glycine max (L.) Merr on the histology and the induction of angiogenesis in the vaginal epithelium of postmenopausal women

• Grant number: 17/20061-5
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2018
• End date: February 29, 2020
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Sonia Maria Rolim Rosa Lima
• Grantee: Sonia Maria Rolim Rosa Lima
• Host Institution: Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP). Fundação Arnaldo Vieira de Carvalho. São Paulo , SP, Brazil
• Associated researchers: Maria Antonieta Longo Galvão da Silva

Abstract

Objective: to analyze the effects of isoflavones derived from Glycine max (L.) Merr vaginally on the histology and induction of vaginal epithelium angiogenesis in postmenopausal women. Methods: Double-blind, randomized, placebo-controlled clinical trial. Sixty-six women were treated for 12 weeks with isoflavone vaginal gel 4% (1 g / day) and 60 women for the same period with placebo gel. Microbiology in the vaginal pouch will be performed before and after 12 weeks of treatment and evaluated in histology and immunohistochemistry for presence and increase of blood vessels. Expected results: Treatment with Glycine max (L.) Merr. 4% vaginal gel daily may be an option for the treatment of vulvovaginal atrophy, being able to improve blood supply to the mucosa and relieve symptoms in postmenopausal women. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIMA, S. M. R. R.; HONORATO, J. V.; SILVA, M. A. L. G.. Glycine Max (L.) Merr isoflavone gel improves vaginal vascularization in postmenopausal women. CLIMACTERIC, APR 2020. (17/20061-5)

LIMA, S. M. R. R.; HONORATO, J. V.; SILVA, M. A. L. G.. Glycine Max (L.) Merr isoflavone gel improves vaginal vascularization in postmenopausal women. CLIMACTERIC, v. 23, n. 5, p. 6-pg., 2020-04-25. (17/20061-5)