Antigen-presenting capacity comparison among macrophages, B cells and dendritic cells in DNA vaccine model

• Grant number: 05/03087-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2006
• End date: July 31, 2007
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Arlete Aparecida Martins Coelho-Castelo
• Grantee: Luciana Previato de Almeida
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

DNA vaccine is constructs whereas the gene cloned in plasmid from bacteria origin can be expressed into eukaryotic cell to give protection against determinates micro organism. The main vantage of theses kind of vaccination is has the same effect of that attenuates vaccines, with a better cost effective production and safety. After intramuscular DNA injection several APC from bone medulla or present in local site can uptake DNA and make antigen presentation in secondary lymphoid tissue. Interesting B cell can also uptake and present the antigen. However, the participation of B cells in the induction of immune response, in DNA vaccines, so quite understands.In this way, the aim of the project are analysis the participation of B cells in the immune response after DNA immunization and compare these phenomena with other APC, like macrophages and dendritic cells. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ALMEIDA, Luciana Previato de. Analysis of different APC in DNA vaccines and the main role of B cells in this vaccine model. 2008. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.