Chemical study of signaling substances produced by higher bacteria and eukaryotes

• Grant number: 05/02934-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2006
• End date: February 29, 2008
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Anita Jocelyne Marsaioli
• Grantee: Armando Mateus Pomini
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This project aims to study many aspects involved in bacterial communication systems based on the production and detection of acyl-homoserine lactones signalling substances. In phytopathogenic bacteria, it will be characterized the acyl-homoserine lactones produced by Erwinia rhapontici, and to investigate if this substances can control the expression of pigments/siderophores in this species. The bacterial communication will also be studied in Gluconacetobacter diazotrophicus, which represents an important bacterial strain due to its capacity to fix atmospheric nitrogen in sugarcane tissues. Finally, the interferences of eukaryots in the bacterial communication processes will be studied through the bio-guided fractionation of maize leaves extracts, in order to investigate the production of substances with the same biological activity of acyl-homoserine lactones (agonists). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CABECA, LUIS FERNANDO; POMINI, ARMANDO MATEUS; CRUZ, PEDRO LUIZ R.; MARSAIOLI, ANITA J.. Binding Events of (S)-N-(3-Oxo-octanoyl)-homoserine Lactone with Agrobacterium tumefaciens Mutant Cells Studied by Saturation Transfer Difference NMR. Journal of the Brazilian Chemical Society, v. 22, n. 4, p. 702-708, 2011. (05/02934-4)

POMINI, ARMANDO MATEUS; MACHADO, GLAUCO; PINTO-DA-ROCHA, RICARDO; MACIAS-ORDONEZ, ROGELIO; MARSAIOLI, ANITA J.. Lines of defense in the harvestman Hoplobunus mexicanus (Arachnida: Opiliones): Aposematism, stridulation, thanatosis, and irritant chemicals. Biochemical Systematics and Ecology, v. 38, n. 3, p. 300-308, JUN 2010. (05/02934-4, 08/06604-7)

POMINI, ARMANDO M.; CRUZ, PEDRO L. R.; GAI, CLAUDIA; ARAUJO, WELINGTON L.; MARSAIOLI, ANITA J.. Long-Chain Acyl-Homoserine Lactones from Methylobacterium mesophilicum: Synthesis and Absolute Configuration. Journal of Natural Products, v. 72, n. 12, p. 2125-2129, DEC 2009. (05/02934-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

POMINI, Armando Mateus. Acyl-homoserine lactones from the phytopathogenic bacteria Pantoea ananatis and Methylobacterium mesophilicum and chemical defense in the harvestman Hoplobunus mexicanus. 2009. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.