SR-BI and ABCA1 in small intestine, liver and kidney in offspring of mother fed with hiperlipidic diet

• Grant number: 10/06771-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2010
• End date: July 31, 2012
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Jose Antonio Rocha Gontijo
• Grantee: Luiz Fernando Possignolo
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The increased incidence of metabolic disorders related to lipid metabolism such as obesity, atherosclerosis, metabolic syndrome and other dyslipidemias are related to changes in dietary habits during the last decades, in which there is an increase in fat intake. Studies have shown that a high-fat diet can cause changes in various organs such as liver, kidneys and intestine, because they are directly linked to lipid metabolism, and they express receptors responsible for uptake and transport of these. During pregnancy and lactation the diet consumed by the mother can influence on offspring, leading him to a predisposition to a variety of disorders. The ABCA1 protein is directly responsible for the efflux of cellular cholesterol and phospholipids to apolipoprotein AI (ApoA-I), the absence or reduction of the function can cause serious complications, because the Apo-I-free lipids is rapidly removed by the kidneys avoiding the formation of HDL. SR-BI is a membrane receptor that can also mediate the selective uptake of cholesteryl esters from HDL and LDL to the cells, ant it promotes the efflux of free cholesterol to lipoproteins. Thus, these cholesterol transporters proteins are considered a potent anti-atherogenic. Given the information presented, the aim of this study is to verify the effects of a maternal high-fat diet on cholesterol transport proteins SR-BI and ABCA1 in the small intestine, liver and kidney of the offspring at different stages of postnatal development.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

POSSIGNOLO, Luiz Fernando. Effect of high fat diet chronic ingestion on the metabolism of female rats, and on the SR-BI and ABCA1 expression in the placenta, small intestine, liver and kidney of the offspring. 2012. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.