EXPRESSION OF DIFFERENTS METALO-PROTEINASES AND COLLAGEN TYPE IV IN THE CORNEA OF RABBITS TREATED TOPICALLY WITH 0,5% MORPHINE AFTER LAMELAR KERATECTOMY

• Grant number: 07/06519-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2008
• End date: November 30, 2010
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: José Luiz Laus
• Grantee: Alexandre Pinto Ribeiro
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

To study the effects of topical 0.5% morphine upon corneal healing evaluating the expression of metalloproteinases-1,-9, and collagen type IV in ulcers experimentally-induced in rabbits. Two groups will be formed (n=14). One will receive topical 0.5% morphine and the other saline. Clinical evaluation, histopathology and immunohistochemistry will be assessed in different time points until corneal reepithelization. Parameters will be compared statistically (P<0,05).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RIBEIRO, ALEXANDRE P.; SILVA, MIGUEL L.; ARAUJO, RODRIGO L.; FERRUCCI, DANILO L.; MINEO, TIAGO; THIESEN, ROBERTO; BANDARRA, MARCIO B.; LAUS, JOSE L.. Expression of matrix metalloproteinases, type IV collagen, and interleukin-10 in rabbits treated with morphine after lamellar keratectomy. VETERINARY OPHTHALMOLOGY, v. 15, n. 3, p. 153-163, MAY 2012. (07/06519-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

RIBEIRO, Alexandre Pinto. Duração do efeito analgésico e expressão de diferentes metaloproteinases, do colágeno tipo IV e da interleucina-10, em córneas de coelhos tratadas com morfina, após ceratectomia lamelar. 2010. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.