Synthesis of selenocarbohydrates and glycoconjugates from D-xylose: Reactivity and evaluation of biological activity

• Grant number: 08/07684-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2009
• End date: February 28, 2011
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Diogo Seibert Lüdtke
• Grantee: Hugo de Campos Braga
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The project is centered on the development of a short synthetic route for the preparation of selenocarbohydrates, derived from D-xylose, with different substitution patterns ate the organoselenium moiety. These products will be used as precursors for the synthesis of interesting synthetic intermediates, such as deoxyglucosides, exo-glucals and Se(IV)-oxacycles. Moreover, we also planned a synthesis of disaccharides and glycoconjugates, where the two basic units are connected by a selenium atom. Some selected compounds will be evaluated in anti-oxidant, analgesic and anti-inflammatory assays.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BRAGA, Hugo de Campos. Synthesis of seleno-carbohydrates and preliminary evaluation of biological activity. 2011. Master's Dissertation - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.