Effect of resistance exercise on modulation of skeletal muscle atrophy dexamethasone-induced

• Grant number: 09/02896-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: September 01, 2009
• End date: August 31, 2010
• Field of knowledge: Health Sciences - Nutrition
• Principal Investigator: Antonio Herbert Lancha Junior
• Grantee: Humberto Nicastro Silva
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The reversion/atenuation of skeletal muscle atrophy is an important framework to be investigated in several conditions able to induce it, such as immobilization-induced skeletal muscle disuse. Although skeletal muscle disuse phenomenon is widely studied, there is a lack of well controlled nutritional studies in current literature that assist the development of potential anti-atrophic strategies. This study aims to evaluate the effect of leucine supplementation isolated or combined (BCAA) on immobilization-induced (knee brace) skeletal muscle atrophy due to surgical reconstruction of anterior cruciate ligament (ACL). Male and physically active adult subjects will be randomized into 3 groups: leucine, BCAA or placebo supplementation. Both groups will be composed by subjects who underwent the procedure of ACL reconstruction. Supplementation protocol will start from 10 days prior knee surgery to 7 days after it without exercise or active rehabilitation protocol. We intend to verify the effectiveness of leucine supplementation on structure and function of quadriceps muscle and, furthermore, the possible cellular mechanisms involved in muscle remodeling and modulated by these interventions in order to propose a possible nutritional anti-atrophic strategy.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NICASTRO, HUMBERTO; ARTIOLI, GUILHERME GIANNINI; COSTA, ANDRE DOS SANTOS; SOLIS, MARINA YAZIGI; DA LUZ, CLAUDIA RIBEIRO; BLACHIER, FRANCOIS; LANCHA, JR., ANTONIO HERBERT. An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions. Amino Acids, v. 40, n. 2, p. 287-300, FEB 2011. (09/02896-6)

PAINELLI, VITOR DE SALLES; NICASTRO, HUMBERTO; LANCHA, JR., ANTONIO H.. Carbohydrate mouth rinse: does it improve endurance exercise performance?. NUTRITION JOURNAL, v. 9, AUG 27 2010. (09/02896-6)