Synthesis and biological evaluation of phosphates, hosphoramides and carbamate derived from dihydropyranones

• Grant number: 09/04627-2
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2009
• End date: July 31, 2011
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Ronaldo Aloise Pilli
• Grantee: Vanêssa Caixeta Pereira
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The syntheses of organic phosphates, phosphoramides and carbamate derived from dihydropyranones will be carried out based on the structure of goniothalamin as the lead compound. These derivatives will be evaluated against 9 human cancer cell lines and as inhibitors of phosphatases and chaperones (Hsp90).

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PEREIRA, Vanêssa Caixeta. Synthesis and biological evaluation of derivatives goniotalamina. 2011. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.