Modulation of renal renin-angiotensin system and inflammatory mechanisms in prenatally programmed hypertension

• Grant number: 09/14006-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): December 01, 2009
• Effective date (End): January 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Dulce Elena Casarini
• Grantee: Ingrid Kazue Mizuno Watanabe
• Host Institution: Departamento de Medicina. Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Over the last decades, the growing body of evidence supports the concept that adverse prenatal environmental factors predispose individuals to the development of diseases, including cardiovascular diseases in their adulthood. Changes in nutritional supply during fetal development appear to be a strong signal initiator of adaptive processes, which result in physiological, morphological and metabolic changes, triggering deleterious and lasting effects on health in adulthood, including the profile of blood pressure. Prenatal programming of hypertension is associated with abnormalities of the renin-angiotensin system in the kidney, which may be related to oxidative tissue stress caused by angiotensin II (Ang II) via AT1 receptor and by infiltrating immune cells. Ang II also participates in the regulation of vascular inflammatory response by stimulating the recruitment of inflammatory cells, which can produce Ang II, perpetuating the inflammatory cycle. The aim of the project is to verify the modulation of the renal RAS and the inflammatory mechanisms by the prenatal programming in the adulthood. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

WATANABE, I. K. M.; JARA, Z. P.; VOLPINI, R. A.; FRANCO, M. D. C.; JUNG, F. F.; CASARINI, D. E.. Up-regulation of renal renin-angiotensin system and inflammatory mechanisms in the prenatal programming by low-protein diet: beneficial effect of the post-weaning losartan treatment. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, v. 9, n. 5, p. 530-535, OCT 2018. (09/14006-5)